目的探討原發性膽囊癌治療的措施。方法對我院1998年4月至2003年2月外科治療的122例原發性膽囊癌患者的臨床資料，結合部分患者隨訪結果進行分析總結。結果19例Ⅰ、Ⅱ及Ⅲ期膽囊癌患者手術治療效果滿意； 103例Ⅳ、Ⅴ期膽囊癌患者中34例行根治或擴大根治術，根治切除率為33.0%，余69例行姑息性手術治療，行膽囊癌根治術后患者的平均生存時間明顯長于姑息性手術者（17.6個月 vs 7.3個月）。結論對膽囊癌應采取積極的、個體化的治療措施。擴大根治術可使部分Ⅳ、Ⅴ期膽囊癌患者受益。應注意淋巴結清掃的范圍和做到無殘留癌的根治性切除。對綜合治療的研究還需進一步深入。
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Varshney S, Buttirini G, Gupta R. Incidental carcinoma of the gallbladder [Ｊ]. Eur J Surg Oncol, 2002; 28(1)∶4.
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Shimada H, Endo I, Togo S, et al. The role of lymph node dissection in the treatment of gallbladder carcinoma [Ｊ]. Cancer, 1997; 79(5)∶892.
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Kondo S, Nimura Y, Hayakawa N, et al. Regional and paraaortic lymphadenectomy in radical surgery for advanced gallbladder carcinoma [Ｊ]. Br J Surg, 2000; 87(4)∶418.
7.
Oohashi Y, Shirai Y, Wakai T, et al. Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible [Ｊ]. Cancer, 2002; 94(11)∶3000.
8.
Kresl JJ, Schild SE, Henning GT, et al. Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma [Ｊ]. Int J Radiat Oncol Biol Phys, 2002; 52(1)∶167.
1. Muratore A, Polastri R, Capussotti L. Radical surgery for gallbladder cancer: current options [Ｊ]. Eur J Surg Oncol, 2000; 26(5)∶438.
2. Suzuki K, Kimura T, Ogawa H. Is laparoscopic cholecystectomy hazardous for gallbladder cancer? [Ｊ]. Surgery, 1998; 123(3)∶311.
3. Z’graggen K, Birrer S, Maurer CA, et al. Incidence of port site recurrence after laparoscopic cholecystectomy for preoperatively unsuspected gallbladder carcinoma [Ｊ]. Surgery, 1998; 124(5)∶831.
4. Varshney S, Buttirini G, Gupta R. Incidental carcinoma of the gallbladder [Ｊ]. Eur J Surg Oncol, 2002; 28(1)∶4.
5. Shimada H, Endo I, Togo S, et al. The role of lymph node dissection in the treatment of gallbladder carcinoma [Ｊ]. Cancer, 1997; 79(5)∶892.
6. Kondo S, Nimura Y, Hayakawa N, et al. Regional and paraaortic lymphadenectomy in radical surgery for advanced gallbladder carcinoma [Ｊ]. Br J Surg, 2000; 87(4)∶418.
7. Oohashi Y, Shirai Y, Wakai T, et al. Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible [Ｊ]. Cancer, 2002; 94(11)∶3000.
8. Kresl JJ, Schild SE, Henning GT, et al. Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma [Ｊ]. Int J Radiat Oncol Biol Phys, 2002; 52(1)∶167.
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