COPD患者血漿白細胞介素-13與白三烯B4水平變化的研究_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

于潁佳 ,  許西琳

Corresponding?author：

許西琳, Email: xuxilin@yahoo.com.cn

Keywords：

慢性阻塞性肺疾病; 白細胞介素13; 白三烯B4

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目的探討COPD 患者急性加重期和穩定期血漿IL-13 與白三烯B4 ( LTB4 ) 水平的變化。方法收集符合納入標準的COPD 患者30 例, 以健康志愿者30 例作為對照。比較COPD 患者急性加重期、穩定期血漿IL-13 與LTB4 水平, 并與正常對照組比較, 對IL-13 與LTB4 進行相關分析。結果 COPD 急性加重期患者血漿IL-13 與LTB4 水平分別為( 31. 13 ±4. . 59) pg/mL 和( 339. 52 ±45. 50) pg/mL, 在穩定期分別為( 20. 72 ±4. 39) pg/mL 和( 196. 71 ±53. 85) pg/mL, 均較正常對照組顯著增高[ ( 6.04 ±1. 58) pg/mL 和( 63. 36 ±11. 82) pg/mL, P 均 lt; 0. 05] , 急性加重期IL-13 與LTB4水平顯著高于穩定期( P 均 lt;0. 05) 。急性加重期和穩定期血漿IL-13 水平與LTB4 水平均呈明顯正相關( r =0. 985, r =0. 970; P = 0. 000) 。結論 IL-13 和LTB4 可以作為反映COPD 病情的免疫學指標, 可通過監測IL-13 和LTB4 水平來反映病情變化及指導治療。

Citation： 于潁佳,許西琳. COPD患者血漿白細胞介素-13與白三烯B4水平變化的研究. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(2): 190-191. doi: Copy

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1. Barnett M.Management of end-stage chronic obstructive pulmonary disease. Br J Nurs, 2008, 17: 1390-1394.
2. Sadeghnejad A, Meyers DA, Bottai M, et al. IL-13 promoter polymorphism 1112C/ T modulates the adverse effect of tobacco smoking on lung function. AmJ Respir Crit Care Med, 2007,176:748-752.
3. Rubin P, Mollison KW. Pharmacotherapy of diseases mediated by 5 -lipoxygenase pathway eicosanoids. Prostaglandins Other Lipid Mediat, 2007, 83: 188-197.
4. Zheng T, Zhu Z, Wang Z, et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest, 2000, 106: 1081-1093.
5. Hacievliyagil SS, Gunen H, Mutlu LC, et al. Association between cytokines in induced sputum and severity of chronic obstructive pulmonary disease. Respir Med, 2006, 100: 846-854.
6. Bowles KS, Beadle RE, Mouch S, et al. A novel model of equine recurrent airway obstruction. Vet Immunol Immunopathol, 2002, 87:385-389.
7. Cohn L, Whittaker L, Niu N, et al. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Found Symp,2002, 248: 201-213.
8. Tanino M, Betsuyaku T, Takeyabu K, et al. Increased levels of interleukin-8 in BAL fluid from smokers susceptible pulmonary emphysema. Thorax, 2002, 57: 405-411.
9. Beeh KM, Kornmann O, Buhl R, et al. Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest, 2003, 123: 1240-1247.
10. Vargaftig BB, Singer M. Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. Am J Physiol Lung Cell Mol Physiol, 2003, 284: L260-L269.
11. Vargaftig BB, Singer M. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol, 2003, 28: 410-419.

Chinese Journal of Respiratory and Critical Care Medicine

COPD患者血漿白細胞介素-13與白三烯B4水平變化的研究

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