肺上皮樣血管內皮細胞瘤一例并文獻復習_Chinese Journal of Respiratory and Critical Care Medicine

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王玉珠 ¹ , 金洪 ² , 姜勇 ³

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Keywords：

肺上皮樣血管內皮細胞瘤; 肺腫

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目的提高對肺上皮樣血管內皮細胞瘤臨床診治的認識。方法報告1 例肺上皮樣血管內皮細胞瘤病例并進行相關文獻復習。結果患者為29 歲男性, 反復咳嗽10 個月。多次胸部CT均顯示雙肺多發性結節影, 臨床診斷為肺癌、結節病、結核。最后經胸腔鏡開胸肺活檢病理診斷為肺上皮樣血管內皮細胞瘤。結合本例并復習近20 年國內外文獻報道的110 例肺上皮樣血管內皮細胞瘤( 國外96 例, 國內14 例) 資料。結果顯示本病女性多見, 發病年齡7 ～83 歲; 咳嗽為常見癥狀, 胸部CT 表現為結節影。確診主要依靠手術病理檢查。目前尚無有效的治療措施。結論肺上皮樣血管內皮細胞瘤是一種罕見病, 臨床無特異性, 極易誤診。

Citation： 王玉珠,金洪,姜勇. 肺上皮樣血管內皮細胞瘤一例并文獻復習. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(6): 641-643. doi: Copy

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4.	Weiss SW, Ishak KG, Dail DH, et al. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol,1986, 3: 259 -287.
5.	Schattenberg T, Kam R, Klopp M, et al. Pulmonary epithelioid hemangioendothelioma: report of three cases. Surg Today, 2008, 38 :844-849.
6.	Bharadwaj R, Hejmadi R, Desai S. Pericardial effusion and raised CA-125 level-unusual manifestations of primary pulmonary epithelioid hemangioendothelioma. Indian J Cancer, 1999, 36: 194 -197.
7.	Travis WD, Brambilla E, Mueller-Hermelink HK, et al. Pathology and genetics of tumours of the lung, pleure, thymus and heart. WHO classification of tumours. Lyon: IARC Press; 2004 .
8.	Fagen K, Silverman ED, Cole RL. et al. Detection of a pulmonary epithelioid hemangioendothelioma by FDG PET Scan. Clin NuclMed, 2004, 29: 758-759 .
9.	Cronin P, Arenberg D. Pulmonary epithelioid hemangioendothelioma:an unusual case and a review of the literature. Chest, 2004, 125:789-793.
10.	Ross GJ, Violi L, Friedman AC, et al. Intravascular bronchioloalveolar tumor: CT and pathologic correlation. J Comp Assist Tomogr, 1989 ,13: 240-243 .
11.	Hanada N, Namai S, Kobayashi C, et al. Case report of pulmonary epithelioid hemangioendothelioma ( in Japanese ) . Nihon Kokyuki Gakkai Zasshi, 2003, 41: 144-149.
12.	Roudier-Pujol C, Enjolras O, Lacronique J, et al. Multifocal epithelioid hemangioendothelioma with partial remission after interferon alpha-2a treatment( in French) . Ann Dermatol Venerol,1994, 121: 898-904.
13.	Bagan P, Hassan M, Le Pimpec Barthes F, et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature. Ann Thorac Surg, 2006, 82: 2010-2013.
14.	Kitaichi M, Nagai S, Nishimura K, et al. Pulmonary epithelioid hemangioendothelioma in 21 patients, including three with partial spontaneous regression. Eur Respir J, 1998, 12: 89-96.

1. Dail DH, Liebow AA, Gmelich JT, et al, Intravascular, bronchiolar,and alveolar tumor of the lung( IVBAT) . An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer, 1983, 51 : 452 -464.
2. Amin RM, Hiroshima K, Kokubo T, et al. Risk factors and independent predictors of survival in patients with pulmonary epithelioid hemangioendothelioma. Review of the literature and a case report. Respirology, 2006, 11: 818 -815.
3. 葉甫登, 張峰. 肺上皮樣血管內皮瘤( 附1 例報告及文獻復習) .臨床肺科雜志, 2007, 12: 332-334 .
4. Weiss SW, Ishak KG, Dail DH, et al. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol,1986, 3: 259 -287.
5. Schattenberg T, Kam R, Klopp M, et al. Pulmonary epithelioid hemangioendothelioma: report of three cases. Surg Today, 2008, 38 :844-849.
6. Bharadwaj R, Hejmadi R, Desai S. Pericardial effusion and raised CA-125 level-unusual manifestations of primary pulmonary epithelioid hemangioendothelioma. Indian J Cancer, 1999, 36: 194 -197.
7. Travis WD, Brambilla E, Mueller-Hermelink HK, et al. Pathology and genetics of tumours of the lung, pleure, thymus and heart. WHO classification of tumours. Lyon: IARC Press; 2004 .
8. Fagen K, Silverman ED, Cole RL. et al. Detection of a pulmonary epithelioid hemangioendothelioma by FDG PET Scan. Clin NuclMed, 2004, 29: 758-759 .
9. Cronin P, Arenberg D. Pulmonary epithelioid hemangioendothelioma:an unusual case and a review of the literature. Chest, 2004, 125:789-793.
10. Ross GJ, Violi L, Friedman AC, et al. Intravascular bronchioloalveolar tumor: CT and pathologic correlation. J Comp Assist Tomogr, 1989 ,13: 240-243 .
11. Hanada N, Namai S, Kobayashi C, et al. Case report of pulmonary epithelioid hemangioendothelioma ( in Japanese ) . Nihon Kokyuki Gakkai Zasshi, 2003, 41: 144-149.
12. Roudier-Pujol C, Enjolras O, Lacronique J, et al. Multifocal epithelioid hemangioendothelioma with partial remission after interferon alpha-2a treatment( in French) . Ann Dermatol Venerol,1994, 121: 898-904.
13. Bagan P, Hassan M, Le Pimpec Barthes F, et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature. Ann Thorac Surg, 2006, 82: 2010-2013.
14. Kitaichi M, Nagai S, Nishimura K, et al. Pulmonary epithelioid hemangioendothelioma in 21 patients, including three with partial spontaneous regression. Eur Respir J, 1998, 12: 89-96.

Chinese Journal of Respiratory and Critical Care Medicine

肺上皮樣血管內皮細胞瘤一例并文獻復習

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