【摘要】 目的 分析腺苷蛋氨酸治療慢性乙型肝炎高膽紅素血癥的臨床療效。 方法 回顧性分析2010年1-12月28例接受腺苷蛋氨酸（2 000 mg靜脈滴注，1次/d）治療慢性乙型肝炎高膽紅素血癥患者的臨床資料，并對腺苷蛋氨酸治療慢性重癥乙型肝炎高膽紅素血癥后癥狀、體征及實驗室檢測指標的改變情況進行總結，利用多因素logistic回歸分析方法探索與療效相關的預測因素。根據相關癥狀、體征和實驗室結果的不同，將療效分為顯效、有效和無效3類。 結果 28例患者使用腺苷蛋氨酸治療4周后，顯效20例（71.4%），有效4例（14.3%），無效4例（14.3%）。多因素logistic回歸分析提示病程短、并發癥少是影響腺苷蛋氨酸療效的獨立預測因素。 結論 腺苷蛋氨酸是治療慢性乙型肝炎高膽紅素血癥有效，發病時間短及并發癥少的患者退黃效果更好。
【Abstract】 Objective To investigate the curative efficacy of ademetionine in the treatment of hyperbilirubinemia for chronic hepatitis B patients. Methods The clinical data of 28 chronic hepatitis B patients with intrahepatic cholestasis receiving intravenous ademetionine treatment (2 000 mg per day) were retrospectively analyzed. Patients’ symptoms, body signs and laboratory examination results were summarized, and predictors for efficacy were investigated using multiple regression analysis. In this study, the curative efficacy was classified into remarkable efficacy, efficacy and inefficacy, according to the clinical data. Results After one-month treatment with ademetionine, the percentage for remarkable efficacy, efficacy and inefficacy was 71.4%, 14.3%, and 14.3% respectively. Multivariate logistic regression analysis showed that short disease duration and fewer complications were independent predictors for remarkable efficacy of ademetionine treatment. Conclusion Ademetionine is an effective agent for the treatment of hyperbilirubinemia in chronic hepatitis B patients, and the result is especially good for patients with short duration and fewer complications.
引用本文： 劉鋒,宋曉蓉,賈彬,朱利紅. 腺苷蛋氨酸治療慢性乙型肝炎高膽紅素血癥. 華西醫學, 2011, 26(9): 1284-1286. doi: 復制