【摘要】 目的 探討海洋肽對惡性腫瘤化學治療（簡稱化療）患者營養狀況和免疫功能的影響。 方法 依照納入排除標準選取2010年3－11月66例惡性腫瘤化療患者，隨機分為試驗組和對照組，每組各33例。在正常飲食基礎上，試驗組和對照組分別服用海洋肽制劑和乳清蛋白制劑21 d，進行肝腎功能、營養狀況及免疫指標的測定。 結果 干預前后兩組肝腎功及血脂指標差異無統計學意義（Pgt;0.05），且均在正常范圍內。試驗組干預后體質指數（body mass index，BMI）、上臂圍、上臂肌圍、總蛋白、白蛋白、球蛋白、前白蛋白（prealbumin，PA）、轉鐵蛋白較干預前升高有統計學意義（Plt;0.05），而血紅蛋白和三頭肌皮褶厚度干預前后比較差異無統計學意義（Pgt;0.05）；對照組干預前后各指標差異均無統計學意義（Pgt;0.05）；試驗組BMI、PA的前后差值較對照組高（Plt;0.05），而其他指標差值在兩組間差異無統計學意義（Pgt;0.05）。兩組在干預前后組內比較及組間免疫指標差值比較，差異均無統計學意義（Pgt;0.05）。 結論 海洋肽作為部分氮源應用于惡性腫瘤化療患者，對患者的內臟蛋白、人體測量等均有一定的營養改善作用，但對免疫功能的影響不明顯，尚待進一步研究。【Abstract】 Objective To investigate the effects of marine peptide on the nutritional status and immune function in malignant tumor patients undergoing chemotherapy. Methods According to inclusive and exclusive criteria, 66 malignant tumor patients undergoing chemotherapy from March 2010 to November 2010 were randomized into study group and control group with 33 patients in each group. The patients in the study group were given marine collagen peptide whey protein while those in the control group were given whey protein for 21 days. Liver and kidney function, nutritional status and immune function were observed before and after intervention. Results Liver, kidney function and blood lipids of all the patients were within normal range, and were not significantly different between the two groups before and after intervention (P＞0.05). After intervention, body mass index (BMI), arm circumference, arm muscle circumference, total protein, albumin, globulin, prealbumin (PA), transferring protein of the study group were significantly increased (P＜0.05), but hemoglobin and triceps skinfold thickness had no significant changes (P＞0.05). There was no significant difference of the above parameters in the control group before and after intervention (P＞0.05). The magnitude of change of PA and BMI before and after intervention were higher in the study group than those in the control group (P＜0.05), while the magnitude of change of other parameters before and after intervention showed no significant difference between the two groups (P＞0.05). The immune function showed no significant change in both groups before and after intervention (P＞0.05), and it was also not significantly different between the two groups. Conclusion As part of dietary nitrogen sources, marine peptide can significantly improve nutritional status, including visceral protein and anthropometry in malignant tumor patients undergoing chemotherapy, but it has no significant effect on immune function, which should be further studied in detail.
ObjectiveTo summarize the results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibody, total antibody and cellular immune function of COVID-19 convalescent patients one year after discharge, and to analyze the correlation between the SARS-CoV-2 antibody and the indexes of immune function. MethodsA total of 41 confirmed COVID-19 patients discharged from Chengdu Public Health Clinical Medical Center from January to April 2020 and followed up one year after discharge were included in the study as the research group, including 18 males and 23 females with an average age of 47.83±12.95 years. The results of SARS-CoV-2 IgG, total antibody and immune function indexes one year after discharge were collected in order to discuss the correlation of SARS-CoV-2 and cellular immune function. A total of 40 healthy employees of the hospital vaccinated against COVID-19 were randomly selected as the vaccine group, including 10 males and 30 females with an average age of 43.90±6.86 years. The SARS-CoV-2 antibodies between the two groups were compared. ResultsCD8+T cell count was higher and CD4+T/CD8+T was lower in male patients than those in female patients (all P<0.05). The IgG and total antibodies in patients with re-detectable positive RNA test were both higher than those in patients without re-detectable positive RNA test, but the differences were not statistically significant (P=0.158, 0.060). The positive rate of SARS-CoV-2 IgG in the research group was 80.5% (33/41). SARS-CoV-2 IgG was positively correlated with total antibody (P<0.001). There was a positive correlation between CD4+T cell count and SARS-CoV-2 IgG (r=0.455, P=0.003). The positive rate of SARS-CoV-2 IgG, SARS-CoV-2 IgG amount and total antibody amount in the research group were significantly higher than those in the vaccine group (all P<0.001). ConclusionSARS-CoV-2 IgG of most COVID-19 patients one year after discharge is positive, and their SARS-CoV-2 total antibody is significantly higher than people vaccinated against COVID-19, which suggests that patients infected with SARS-CoV-2 can obtain lasting protection, but the protection may be gradually weaken over time. The degree of antibody attenuation in patients with re-detectable positive RNA test may be weaker. In the convalescence stage, the dynamics of SARS-CoV-2 IgG may be closely related to cellular immune function.
ObjectiveTo explore the effects of pilose antler blood wine on bone mineral density and T-lymphocyte subsets of ovariectomized female Sprague Dawley (SD) rats.
MethodsSixty female SD rats were randomly divided into six groups:normal control group, osteoporosis model group, pure ethylalcohol group, high dose of pilose antler blood wine group, medium dose of pilose antler blood wine group and low dose of pilose antler blood wine group. Normal control group and osteoporosis model group were given saline with the dose of 9.1 g/(kg·d). Pure ethylalcohol group was given pure ethylalcohol with the dose of 9.1 g/(kg·d). The doses of pilose antler blood wine were 4.5, 9.1 and 13.6 g/(kg·d) respectively in low, medium and high dose of pilose antler blood wine group. After the feeding of pilose antler blood wine for 30 days, the bone mineral density and T-lymphocyte subsets of rats were assessed.
ResultsThe difference in bone mineral density among the three pilose antler blood wine groups was significant (P<0.05); the most obvious improvement of one mineral density was found in low and medium dose of pilose antler blood wine groups (P<0.05). The CD4+ T cells and CD4+/CD8+ significantly increased and CD8+ T cells proportion decreased significantly in pilose antler blood wine group compared with those in the osteoporosis model group (P<0.05). CD4+ T cells in medium dose group increased obviously compared with that in the high dose group (P<0.05). CD4+/CD8+ in low and medium dose groups obviously increased compared with that in high dose group (P<0.05). CD4+ T cells of medium dose group obviously increased compared with that in pure ethylalcohol group (P<0.05). CD8+ T cells in medium and low dose groups obviously decreased compared that in pure ethylalcohol group (P<0.05). CD4+/CD8+ in the three dose groups increased significantly compared with that in pure ethylalcohol group (P<0.05).
ConclusionTree different doses of pilose antler blood wine could prevent the osteoporosis and improve the immune function. The effects of medium and low dose of groups were more obvious.
目的：觀察卡介菌多糖核酸注射液在小兒咳嗽變異性哮喘治療應用的療效。方法：將本科40例咳嗽變異性哮喘患兒，隨機分為治療組和對照組(各20例)。治療組給予BCG-PSN+必可酮氣霧劑，對照組：給予單用必可酮氣霧劑吸入，連續吸入6周，觀察療效，并進行統計學處理。結果：治療組總有效率為95%，對照組總有效率為70%，統計學處理總有效率有顯著差異(Plt;0.01)。結論：卡介菌多糖核酸(polysaccharide nucleic acidfraction of BCG，BCG-PSN)能有效地控制咳嗽變異性哮喘(CVA)的呼吸道的反復感染，提高免疫功能；與必可酮配合，能有效地控制CVA的復發。
Objective To summarize the role of the relationship between liver cancer and cellular immunological function, and the role of immune therapy in clinical application. Methods To analyze the relationship between liver cancer and cellular immunological function, and the present research situation of immune therapy for liver cancer in clinical application retrospectively via review the related domestic and foreign literatures. Results The cellular immune dysfunction existed in all liver cancer patients. The state of body’s cellular immunological function is closely related with the arising and development of liver cancer, and the lowness of cellular immunological function is an important factor of hepatocellular carcinoma hard to cure or recurrence and metastasis. Immune therapy plays an important role in the treatment of liver cancer by adjusting the body’s cellular immunological function. Conclusions Liver cancer is closely related with the body’s cellular immunological function. Immune therapy is expected to offer a new way for the treatment of liver cancer, which can also be used as an important auxiliary treatment way.
