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Clinical Analysis of 105 Patients with Postmenopausal Hydrohystera

目的 探討絕經后宮腔積液的病因及診治方法。 方法 對105例絕經后陰道B型超聲（TVS）檢查所示宮腔積液的患者進行回顧性分析。 結果 105例患者中，陰道炎患者31例，占29.52%；其余74例患者行宮腔鏡檢查顯示，宮腔點狀出血29例，占27.62%，宮腔透明粘液23例，占21.90%，另有22例宮腔鏡下未見異常，占20.95%。74例接受宮腔鏡檢查患者因診刮未刮出內膜組織，行宮腔細胞學涂片，病理檢查結果均未見惡性腫瘤細胞，其中16例患者查見炎性細胞。 結論 絕經后無子宮內膜增厚的宮腔積液多由炎癥引起，應及早明確診斷。宮腔鏡現已成為宮腔內病變診斷的金標準，其作為絕經后宮腔積液的病因診斷手段具有臨床實用價值。

The Clinico-pathological Features of Malignant Breast Lymphoma

【摘要】　目的　探討乳腺惡性淋巴瘤的臨床病理特征、治療方式及其與預后關系。　方法　1980年1月-2007年12月對收治的21例乳腺惡性淋巴瘤患者的臨床病理特點、診斷和治療方法進行回顧性分析。　結果　21例乳腺惡性淋巴瘤患者均為女性，中位年齡47歲；其中原發性乳腺惡性淋巴瘤18例，繼發性惡性淋巴瘤3例。原發性乳腺惡性淋巴瘤均為非霍奇金淋巴瘤，B細胞來源為主，大多為術后診斷，治療均采用手術+化學療法。　結論　乳腺惡性淋巴瘤治療應強調手術，化學療法和放射治療的綜合治療。【Abstract】　Objective　To study the clinico-pathological features and treatment modality of malignant breast lymphoma, and their relationships with the prognosis of the disease.　Methods　The clinico-pathological features, diagnosis and treatment methods of 21 cases of malignant breast lymphoma diagnosed between January 1980 and December 2007 were analyzed retrospectively and related domestic and overseas literature was reviewed.　Results　Among the 21 female patients, 18 had primary breast lymphoma (PBL), 3 had secondary breast lymphoma. All cases of PBL were non-Hodgkin’s lymphoma with mainly B cells as the origin. The median age of the patients was 46.5 years old. Most of the cases were diagnosed postoperatively and all patients were treated by operation combined with chemotherapy. Related literature reviewing showed that clinical staging and treatment modality were important factors of prognosis.　Conclusion　In treating malignant breast lymphoma, operation and chemoradiotherapy should be combined together to get a better result.

Study on vascular remodeling, inflammatory response, and their correlations in acute spinal cord injury in rats

ObjectiveTo study the local vascular remodeling, inflammatory response, and their correlations following acute spinal cord injury (SCI) with different grades, and to assess the histological changes in SCI rats.MethodsOne hundred and sixteen adult female Sprague Dawley rats were randomly divided into 4 groups (n=29). The rats in sham group were received laminectomy only. A standard MASCIS spinal cord compactor was applied with drop height of 12.5, 25.0, or 50.0 mm to establish the mild, moderate, or severe SCI model, respectively. Quantitative rat endothelial cell antigen 1 (RECA1) and CD68 positive areas and the correlations were studied by double immunofluorescent (DIF) staining at 12 hours, 24 hours, 3 days, 7 days, and 28 days following SCI. Moreover, qualitative neurofilament-H (NF-H) and glial fibrillary acidic protein (GFAP) positive glial cells were studied by DIF staining at 28 days. ELISA was used to detect the levels of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 in spinal cord homogenates at 12 hours, 24 hours, and 3 days, and the correlations between TNF-α, IL-1β, or IL-6 levels and microvascular density (RECA1) were accordingly studied. Moreover, the neural tissue integrity and neuron damage were assessed by HE staining at 12 hours, 24 hours, 3 days, 7 days, and 28 days, and Nissl’s staining at 28 days following SCI, respectively.ResultsDIF staining revealed that the ratio of RECA1 positive area was the highest in moderate group, higher in mild and severe groups, and the lowest in sham group with significant differences between groups (P<0.05). The ratio of CD68 positive area was the highest in severe group, higher in moderate and mild groups, and the lowest in sham group with significant differences between groups (P<0.05), except the comparisons between mild and moderate groups at 24 hours and 28 days after SCI (P>0.05). There was no significant correlation between the RECA1 and CD68 expressions in sham group at different time points (P>0.05). At 12 and 24 hours after SCI, the RECA1 and CD68 expressions in mild and moderate groups showed significant positive correlations (P<0.05), while no significant correlation was found in severe group (P>0.05). No significant correlations between the RECA1 and CD68 expressions was shown in all SCI groups at 3 days and in severe group at 7 days (P>0.05), while the negative correlations were shown in mild and moderate groups at 7 days, and in all SCI groups at 28 days (P<0.05). In mild, moderate, and severe groups, the axons became disrupted, shorter and thicker rods-like, or even merged blocks with increased injury, while the astrocytes decreased in number, unorganized and condensed in appearance. ELISA studies showed that TNF-α, IL-1β, and IL-6 levels in sham group were significantly lower than those in other 3 groups at different time points (P>0.05). The differences in TNF-α, IL-1β, and IL-6 levels between SCI groups at different time points were sinificant (P<0.05), except IL-1β levels between the mild and moderate groups at 12 hours (P>0.05). Three inflammatory factors were all significantly correlated with the microvascular density grades (P<0.05). Histological analysis indicated that the damage to spinal cord tissue structure correlated with the extent of SCI. In severe group, local hemorrhage, edema, and infiltration of inflammatory cells were found the most drastic, the grey/white matter boundary was disappeared concurrently with the formation of cavity and shortage of normal neurons.ConclusionIn the acute stage following mild or moderate SCI, progressively aggravated injury result in higher microvessel density and increased inflammation. However, at the SCI region, the relation between microvessel density and inflammation inverse with time in the different grades of SCI. Accordingly, the destruction of neural structures positively relate to the grades of SCI and severity of inflammation.

Efficacy of Cinobufacin for Stomach Cancer: A Systematic Review

目的　系統評價華蟾素治療胃癌的療效。 方法　計算機檢索Cochrane （2011年第3期），PubMed （1966年1月－2011年9月），EMBASE（1974年1月－2011年9月），中國生物醫學數據庫（CBM，1978年1月－2011年9月），維普（1989年1月－2011年9月），中國期刊全文數據庫（1994年1月－2011年9月）；手工檢索相關雜志。納入華蟾素治療胃癌的隨機對照試驗（RCT），對納入的RCT進行質量評價，并用RevMan 5.0軟件進行Meta分析。 結果　共納入9個RCT，Meta分析結果顯示：華蟾素聯合常規化學療法（化療）治療中晚期胃癌的有效率高于常規化療組，且差異有統計學意義[RR=1.23，95%CI（1.03，1.46），P=0.02]，而1年生存率兩組比較差異無統計學意義[RR=1.28，95%CI（0.69，2.36），P=0.43]。 結論　常規化療加華蟾素治療胃癌的療效優于常規化療，但因為納入研究質量較低，尚需高質量、大樣本、長期的隨機對照試驗進一步驗證上述結論。

卵黃樣黃斑營養不良基因三個新的點突變與散發性Best病表現型關系的分析

Multiple factor analysis of intraorbital hemodynamic results in diabetic retinopathy

Objective To determine the affected factors of intraorbital hemodynamic results in diabetic retinopathy (DR) and the risk factors related to the occurrence of DR. Methods Posterior ciliary artery (PCA), central retinal artery (CRA), central retinal vein (CRV), and vortex vein (VV) of 68 patients with DR were measured by color Doppler flow image (CDFI). Thirty-one hemodynamic parameters, including systolic velocity, diastolic velocity, mean velocity, resistive index, pulsatility index and accelerative velocity of ophthalmic artery (OA), and other variates (blood pressure, blood sugar, gender, age, duration of the disease, and so on) were collected and clustered in a principal components analys is following a forward, stepwise logistic regression on these components. Results Nine principal components were extracted from 37 original variates, reflecting the velocity of OA, velocity of PCA, resistance of OA, velocity of CRA,resistance of CRA, resistance of PCA, time-related factor, venous drainage factor and gender factor, respectively. In the result of logistic regression, resistance of OA, velocity of CRA, resistance of PCA, time-related factor, and venous drainage factor were the risk factors related to DR. Conclusion The first risk factor affecting DR is time, and intraorbital hemodynamic abnormity influencing the development of diabetic retinopathy may be the increase of resistance of OA, decrease of velocity of CRA, decrease of resistance of PCA, and increase of venous drainage. (Chin J Ocul Fundus Dis，2004，20：98-100)

Construction Workers Among Migrants- A Vulnerable Population for Accessing Reproductive Health ServicesQualitative Situation Analysis in Chengdu Construction Sites for Project YOLAMI

目的：調查了解成都市建筑工地工作的流動人口工人的生殖健康現狀，為項目的干預打下基礎。方法：采用定量調查和定性研究相結合的方法獲取相關數據和信息。結果和結論：流動人口中的建筑工人的確是一個獲取生殖健康知識和服務方面十分脆弱的人群：1)流動人群中的建筑工人們的健康狀況不容樂觀。他們大都看似健康，但健康知識貧乏、不重視自身生殖健康、尋求健康服務的行為單一且不安全；2)建筑公司和工地基本不允許女工在工期懷孕；除特殊工種外，工人沒有體檢；一般只給工人買工傷險，但沒有醫療保險；3)流動人群中的建筑工人們對性與生殖健康方面的需求是迫切的。但他們求醫難，尋求性與生殖健康服務更難。

Status of Adverse Drug Reactions of Terfenadine on Documents

摘要:目的: 分析特非那定所致不良反應的臨床特征、相關因素,為臨床藥物治療中藥品不良反應的防治提供參考依據。 方法 :檢索1986～2008年國內文獻源特非那定的不良反應資料,并加以分析研究。 結果 :34例不良反應報告中女性明顯多于男性;不良反應以心血管系統損害最多(23例,占6766%),其次為皮膚及附件損害(5例,1470%);不良反應預后較好。 結論 :患者的性別、體質、合并用藥等因素能影響不良反應的發生,對于引起心律失常不良反應臨床應提高警惕,減少不良反應的發生。Abstract: Objective: To analyze the clinical features、correlation factors of ADRs caused by Terfenadine drugs and provide beneficial references for preventing and curing the ADRs. Methods :To collect and analyze the cases of ADRs caused by Terfenadine from medical journals of 19862008 Results :Women were more than men in 34 ADRs;cardiovascular system lesions accounted for 6766%,skin and its appendix lesions accounted for 1470%;ADRs prognosis well. Conclusion :The occurrence of ADRs caused by Terfenadine due to many factors such as sex、age and combination drug,ect. The ADRs caused by second generation antihistamine drugs must be reconstred.

應用Cox模型分析影響胸段食管癌切除術預后的因素

目的 分析影響胸段食管癌切除術后患者預后的因素，探討各因素之間的關系。方法 采用計算機比例風險模型(Cox模型)，對影響胸段食管癌三區域淋巴結清除根治術患者預后的臨床因素進行分析。結果 預后與腫瘤侵及深度、分化程度、臨床分期、淋巴結轉移個數及區域數呈正相關，而與年齡呈負相關(P＜0.01)；性別和腫瘤長度與預后無關。淋巴結轉移個數與腫瘤分化程度和侵及深度呈正相關，與年齡呈負相關(P＜0.01)，且與3年和5年生存率顯著相關(P＜0.01)。本組5年生存率為53.7%。結論 胸段食管癌的預后與腫瘤的侵及深度、分化程度、淋巴結轉移個數、腫瘤的部位及患者年齡等因素密切相關；胸段食管癌三區域淋巴結清除根治術有效地提高了淋巴結轉移陰性和轉移較少患者的生存率。

Meta-analysis of gene-disease association studies: a Bayesian genetic model-free approach and its implementation

The choice of genetic models was main difficulty in the meta-analysis of gene-disease association studies. In this study, we made a further discussion about the genetic model-free approach that proposed by Minelli et al. The program that coded by JAGS and R was carried out to perform the Bayesian procedure. In a real example, several kinds of prior distribution were used, including non-informative prior distribution and external clinical prior information. Especially, compared to Minelli’s study, we introduced clinical prior information. The results indicated that the pooled results were rather robust no matters the prior distribution were non-informative or informative, especially when the number of included studies were large.