【摘要】 目的 研究天麻素注射液治療椎-基底動脈供血不足（vertebrobasilar insufficiency，VBI）的療效和安全性。 方法 檢索CBM、CNKI、VIP、萬方數據庫，檢索時間為各數據庫建庫至2010年5月，納入天麻素注射液對比其他藥物治療VBI的隨機對照試驗（RCT），對納入研究進行方法學質量評價后，采用RevMan 5.0軟件進行Meta分析。 結果 納入8個RCT，涉及受試者648例，均為C級文獻，Meta分析結果顯示:天麻素注射液對比丹參注射液治療VBI，顯效率和總有效率差異均有統計學意義[RR=1.63，95%CI （1.37，1.95）和RR=1.21，95%CI （1.12，1.30）]。 結論 基于當前證據，臨床治療VBI，天麻素注射液療效優于丹參注射液，且安全性較好。【Abstract】 Objective To study the effectiveness and safety of gastrodine injection for vertebrobasilar insufficiency (VBI). Methods Databases of CBM, CNKI, VIP and Wanfang were searched from the time of the establishment till May 2010 and randomized controlled trials (RCT) of gastrodine injection compared with other positive drugs for VBI were included. Quality evaluation and meta-analysis by using RevMan 5.0 were performed. Results A total of 8 grade-C RCTs including 648 cases were gathered. The results of meta-analysis showed that the difference of excellent and effective rates between danshen injection and gastrodine injection for VBI were significant: RR=1.63, 95%CI (1.37, 1.95) and RR=1.21, 95%CI (1.12, 1.30). Conclusion Based on current evidence, compared with danshen injection, gastrodine injection is better and safer for VBI.
