Posterior Scleral Reinforcement is an important surgical procedure for the treatment of pathological myopia. Currently used reinforcement materials mainly include biological materials such as allogeneic sclera, dura mater, and bovine pericardial patches, as well as non-biological materials such as polytetrafluoroethylene and silicone rubber devices. Allogeneic sclera and dura mater, as the most commonly used materials, have well-established surgical techniques but face source limitations, restricting their widespread clinical application. Bovine pericardial patches have improved mechanical properties through cross-linking treatment; perinatal tissues (umbilical cord/amnion) possess anti-inflammatory and regenerative characteristics; and novel biological materials such as silk fibroin hydrogels show potential in animal experiments but have not yet entered clinical validation. Among non-biological materials, expanded polytetrafluoroethylene is notable for promoting tissue integration, while adjustable silicone rubber devices offer new options for complex cases. However, existing materials still have limitations in terms of availability, long-term efficacy, and complications. Except for modified bovine pericardial patches and adjustable silicone rubber devices that have entered the clinical trial stage, most new materials remain in experimental research. Future efforts should strengthen material modification and clinical translation research to address the increasingly severe challenges in pathological myopia treatment.
Objective
To analyze the results of diagnostic pars plana vitrectomy (PPV) in patients with uveitis of unknown cause.
Methods
This is a retrospective case series study. Sixty-five patients (67 eyes) with uveitis of unknown cause were enrolled in this study. There were 31 males (32 eyes) and 34 females (35 eyes). The ages were from 6 to 84 years, with the mean age of (55.00±18.56) years. All eyes were received PPV. Examination of vitreous samples consisted of microbial stains and culture, microbial DNA and antibody detection, cytokine measurement, cytology, flow cytometry and gene rearrangement detection.
Results
Vitreous analysis was positive in 40 of 67 eyes (59.7%). Positive results indicated bacterial endophthalmitis in 20 of 40 eyes (50.0%), lymphoma in 11 eyes (27.5%), viral IgM and IgG increased significantly in 3 eyes (7.5%), fungal endophthalmitis in 3 eyes (7.5%), IgG of toxocara increased significantly in 2 eyes (5.0%), IgG of toxoplasma Gondii increased significantly in 1 eye (2.5%).
Conclusion
The diagnostic yield of vitreous samples in uveitis eyes of unknown cause is 59.7%.
