Objective To investigate the early effectiveness of fixed-bearing unicompartmental knee arthroplasty (FBUKA) in patients with anterior cruciate ligament deficiency (ACLD), and to evaluate postoperative muscle strength and functional recovery through isokinetic muscle strength testing. Methods A retrospective analysis was performed on the clinical data of 181 patients with unilateral medial compartment knee osteoarthritis who underwent FBUKA treatment between January 2023 and June 2024 and met the selection criteria. According to the integrity of the anterior cruciate ligament, the patients were divided into the ACLD group (45 cases) and the anterior cruciate ligament intact (ACLI) group (136 cases). There was no significant difference in baseline data between the two groups (P>0.05), including age, gender, body mass index, affected side, disease duration, and preoperative Hospital for Special Surgery (HSS) score, Lysholm score, and visual analogue scale (VAS) score. A standardized rehabilitation protocol was adopted after surgery. Isokinetic muscle strength parameters [peak torque (PT) and total work (TW) of quadriceps and hamstring, and hamstring-to-quadriceps ratio (H/Q) at angular velocities of 60°/s and 180°/s] and HSS score, Lysholm score, and VAS score were measured preoperatively and at 6 weeks, 3 months, 6 months, and 12 months after operation; posterior tibial slope (PTS) was measured at 12 months after operation. Results All patients were followed up 12-18 months, with a mean of 13.6 months. No complication such as aseptic loosening of the prosthesis, dislocation of the mobile bearing insert, infection, or revision occurred after operation. Isokinetic muscle strength testing showed that at angular velocities of 60°/s and 180°/s, the PT and TW of quadriceps and hamstring significantly decreased and H/Q increased in both groups at 6 weeks after operation when compared with preoperative values (P<0.05); then PT and TW increased gradually, and H/Q decreased gradually. Except for no significant difference at 3 months after operation compared with preoperative values (P>0.05), all indicators were significantly different from preoperative values at 6 and 12 months after operation (P<0.05). There was no significant difference in isokinetic muscle strength parameters between the two groups at any time point before and after operation (P>0.05). The HSS score, Lysholm score, and VAS score at each postoperative time point in both groups significantly improved when compared with preoperative values (P<0.05), and there was no significant difference in each score between the two groups at each postoperative time point (P>0.05). At 12 months after operation, the PTS in the ACLD group was significantly smaller than that in the ACLI group (P<0.05). Conclusion For ACLD patients without anteroposterior knee instability, the isokinetic muscle strength recovery trajectory and clinical functional scores after FBUKA are comparable to those of ACLI patients. For such patients, FBUKA can achieve satisfactory muscle strength and functional recovery, and isokinetic muscle strength testing can provide objective quantitative evidence for postoperative rehabilitation evaluation.
ObjectiveTo explore risk factors and prognosis of unplanned reoperation in patients with malignant tumors of digestive tract. MethodsThe clinical data of patients with malignant tumors of digestive tract underwent unplanned reoperation who treated in the Department of General Surgery, the Northern District of the Shanghai Ninth People’s Hospital from January 2014 to December 2017 were retrospectively collected, and each operation was matched in a ratio of 1∶3 as a case-conontrol study object. The risk factors and prognosis of unplanned reoperation were analyzed by the basic information, surgical related informations, and postoperative relevant informations. ResultsThere were 33 cases of unplanned reoperation in the 588 patients with malignant tumors of digestive tract treated surgically, 8 cases died after the unplanned reoperation. The analysis results showed that the basic diseases, history of previous abdominal surgery, preoperative anemia, the first operative time >4 h and intraoperative blood loss ≥400 mL were the independent risk factors of the unplanned reoperations (P<0.050); the basic diseases, unplanned preoperative hemoglobin <90 g/L and intraoperative blood loss ≥400 mL were the independent factors of death for patients with unplanned reoperation (P<0.050). ConclusionsEffective intervention on independent risk factors associated with unplanned reoperation in patients with digestive tract malignant tumors can reduce incidence of unplanned reoperation in future and improve prognosis.
ObjectiveTo compare difference of therapeutic effects between endoscopic frequency-doubled double pulse neodymium yttrium aluminium garnet (FREDDY) laser and endoscopic traditional mechanical lithotripsy in treatment of common bile duct stones (CBDs).MethodsThe clinical data of 207 patients with CBDs treated with ERCP and lithotripsy in the Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine from March 2009 to March 2019 were analyzed retrospectively, of which 71 cases treated by FREDDY (FREDDY group) and 136 cases treated by mechanical lithotripsy (mechanical group). The success rate of stone removal, operation time, postoperative hospitalization time, hospitalization cost, consumables cost, and complications were compared between the two groups.ResultsThere were no significant differences in the general condition and the preoperative clinical data between the two groups (P>0.05). There was no perioperative death in the two groups. There were no significant differences in terms of the postoperative routine laboratory biochemical indexes, consumables cost, hospitalization cost, and rates of the bleeding, postoperative pancreatitis, perforation and biliary tract infection between the two groups (P>0.05). Although the operation time of the FREDDY group was significantly longer than that of the mechanical group (P<0.05), the success rate of stone removal was significantly higher, the postoperative hospitalization time was shorter, the total complications rate and stone residual rate were significantly lower in the FREDDY group as compared with the mechanical group (P<0.05).ConclusionEndoscopic FREDDY laser lithotripsy has a better curative effect and less complications in treatment of large CBDs than mechanical lithotripsy, but operation time needs further to be improved.
Objective To investigate the neuroprotective effect of conducting hydrogel loaded with tetramethylpyrazine sustained-release microparticles (hereinafter referred to as “TGTP hydrogel”) on spinal cord injury rats. Methods Forty-eight adult female Sprague Dawley rats were randomly divided into 4 groups: sham operation group (group A), model group (group B), conductive hydrogel group (group C), and TGTP hydrogel group (group D), with 12 rats in each group. Only laminectomy was performed in group A, and complete spinal cord transection was performed in groups B, C, and D. Basso-Bettie-Bresnahan (BBB) score was used to evaluate the recovery of hind limb motor function of each group before modeling and at 1, 3, 7, 14, and 28 days after modeling, respectively. At 28 days after modeling, the rats were sacrificed for luxol fast blue (LFB) staining to detect myelin regeneration. Nissl staining was used to detect the survival of neurons. Immunohistochemical staining was used to evaluate the expression of inflammation-related factors [nuclear factor кB (NF-кB), tumor necrosis factor α (TNF-α), and interleukin 10 (IL-10)]. Immunofluorescence staining and Western blot were used to evaluate the expression of neurofilament 200 (NF200). RseultsBBB scores of group A were significantly better than those of the other three groups at all time points after modeling (P<0.05); at 14 and 28 days after modeling, there was no significant difference in BBB scores between groups C and D (P>0.05), but the BBB score of group D was significantly better than that of group B (P<0.05). LFB staining and Nissl staining showed that the structure of neurons and myelin in group A was intact, and the myelin integrity and survival number of neurons in group D were significantly better than those in groups B and C. Immunohistochemical staining showed that the absorbency (A) value of NF-кB and TNF-α in group A were significantly lower than those in groups B and C (P<0.05), the A value of IL-10 was significantly higher than that in the other three groups (P<0.05); the A value of NF-κB in group D was significantly lower than that in groups B and C, the A value of TNF-α in group D was significantly lower than that in group B, while the A value of IL-10 in group D was significantly higher than that in group B (P<0.05). Immunofluorescence staining showed that the structure of neurons and nerve fibers in group A was clear and the fluorescence intensity was high. The fluorescence intensity of NF200 in group D was higher than that in groups B and C, and some nerve fibers could be seen. Western blot analysis showed that the relative expression of NF200 in group A was the highest, and the relative expression of NF200 in group D was significantly higher than that in groups B and C (P<0.05). Conclusion The TGTP hydrogel can effectively promote the recovery of motor function in rats with spinal cord injury, and its mechanism may be related to the regulation of inflammatory response.
