Posterior Scleral Reinforcement is an important surgical procedure for the treatment of pathological myopia. Currently used reinforcement materials mainly include biological materials such as allogeneic sclera, dura mater, and bovine pericardial patches, as well as non-biological materials such as polytetrafluoroethylene and silicone rubber devices. Allogeneic sclera and dura mater, as the most commonly used materials, have well-established surgical techniques but face source limitations, restricting their widespread clinical application. Bovine pericardial patches have improved mechanical properties through cross-linking treatment; perinatal tissues (umbilical cord/amnion) possess anti-inflammatory and regenerative characteristics; and novel biological materials such as silk fibroin hydrogels show potential in animal experiments but have not yet entered clinical validation. Among non-biological materials, expanded polytetrafluoroethylene is notable for promoting tissue integration, while adjustable silicone rubber devices offer new options for complex cases. However, existing materials still have limitations in terms of availability, long-term efficacy, and complications. Except for modified bovine pericardial patches and adjustable silicone rubber devices that have entered the clinical trial stage, most new materials remain in experimental research. Future efforts should strengthen material modification and clinical translation research to address the increasingly severe challenges in pathological myopia treatment.
OBJECTIVE To investigate the adhesive interactions of cells with materials and the effects of material properties on cell adhesion in tissue engineering. METHODS By looking up the recent literatures dealt with adhesive interactions of cells with materials and reviewing previous work on the adhesion of tissue-derived cells to materials. RESULTS The adhesion characteristics of cells to materials not only depend on the nature of materials, including bulk and surface properties, surface modification, surface morphology, net charge, porosity and degradation rate, but also on the expression of cell surface molecules and their interaction with the material. CONCLUSION The quantitative measure and biophysical mechanisms of cell adhesion to materials might be very important in tissue engineering.
