Objective To investigate the effects of ambroxol hydrochloride on surface structure of trachea mucosa in rats injured by intratracheally instilled amikacin. Methods Thirty Wistar rats injured by intratracheally instilled amikacin ( 0. 252 mL/kg) were randomly divided into a control group ( n =15) and an ambroxol group ( n= 15) . The rats in the ambroxol group were intraperitoneally injected with ambroxol hydrochloride ( 70 mg/kg) 5 minutes after amikacin administration. They were all equally divided into five subgroups and sacrificed at 2, 4, 8, 28, 48 hours respectively. Then the samples of 1/3 lower segment of trachea were collected and observed under scanning electron microscope. Results In the control group, the mucous secretion and its stickness were increased. The cilia were found lodged, sticked together, aligned abnormally, abrupt partly, and recovered slowly, with the percentage of damaged area of 98. 2% , 98. 5% , 97. 5%, 92. 7% , 82. 1% at 2, 4, 8,24,48 h, respectively. The injuries of mucosa in the ambroxol group were much milder and recovered more rapidly than those in the control group, with the percentage of damaged area of 85. 7% , 81. 9% , 73. 0% , 61. 9% , 50. 2% at 2, 4, 8, 24, 48 h, respectively. Conclusions Intratracheal instillation of amikacin can cause cilia ultrastructure damage on tracheal mucosa. Ambroxol can promote the recovery process and alleviate airway inflammation.
ObjectiveTo improve the seawater-drowning-induced lung injury model in rats, and investigate the protective effect of resveratrol against seawater-drowning-induced lung injury and its mechanism.MethodsA total of 112 SD healthy rats were randomly assigned into 5 groups: a control group (Group C, n=8), a seawater drowning group (Group S, n=32), a resveratrol prophylactic treatment group (Group S+R, n=32), a resveratrol group (Group R, n=8), and an endotracheal intubation group (Group E, n=32). A modified endotracheal intubation model was developed, and endotracheal intubation was used instead of tracheotomy. Blood gas analysis was performed on the abdominal aorta at each time point, then the rats were sacrificed to obtain their lungs. Lung wet-to-dry ratio (W/D), malondialdehyde (MDA), superoxide dismutase (SOD), myeloperoxidase (MPO) and cysteinyl aspartate specific proteinase (Caspase-3) were measured by enzyme linked immunosorbent assay. The histological sections of rat lungs were stained with haematoxylin-eosin. Groups S+R and R were pretreated with resveratrol (50 mg/kg) through intragastric administration for 3 days; then models were established and the rats were sacrificed 24 hours after the last intragastric administration.ResultsAfter seawater perfusion, arterial oxygen pressure decreased and arterial carbon dioxide pressure increased in blood gas analysis of rats, MDA content increased, MPO and SOD activity decreased, caspase-3 content and W/D ratio increased, as well as lung tissue pathological damage. The resveratrol pretreatment group showed the same change trend, but the damage degree was relatively light.ConclusionsSeawater perfusion can induce respiratory failure, pulmonary edema and hemorrhage in rats. Lung tissue apoptosis may occur when seawater submergence causes lung injury. Resveratrol pretreatment can ameliorate hypoxia and pulmonary edema in rats.
ObjectiveTo investigate the effectiveness of arthroscopic iliopsoas tendon tenotomy at the labral level for iliopsoas cyst complicated with internal snapping hip. Methods A retrospective analysis was conducted on the clinical data of 9 patients diagnosed with iliopsoas cyst and internal snapping hip admitted between April 2021 and June 2023. The cohort consisted of 3 males and 6 females, aged 23-58 years with a mean age of 40.7 years. The disease duration ranged from 11 to 24 months, with an average of 16.7 months. Preoperative MRI showed that 9 cases were complicated with glenoid labrum tear, iliopsoas muscle cyst extended from the glenoid level to the proximal end of the lesser trochanter, and compressed the femoral artery and vein. The iliopsoas tendons were cut at the level of glenoid labrum under arthroscopy. Pincer plasty (7 cases), glenoid labrum repair (6 cases), or glenoid labrum debridement (3 cases) was performed according to the lesions during operation, and the cyst drainage and cyst wall debridement were completed. Imaging examinations were performed before operation and at 2 days after operation to measure the lateral central-edge angle (LCE), α angle, off-set value, and the distance from femoral artery and vein to acetabular rim. The modified Harris Hip Score (mHHS), the 12-item International Hip Outcome Tool (iHOT-12), and the visual analogue scale (VAS) score were used to assess hip function before operation and at last follow-up, and the hip flexion and external rotation muscle strength in supine position were compared. ResultsAll patients completed the surgery successfully. The operation time ranged from 50 to 92 minutes (mean, 67.3 minutes), and intraoperative blood loss was 10-25 mL (mean, 18.9 mL). Pain and snapping symptoms resolved immediately after operation, and no complications such as femoral nerve injury, femoral arteriovenous injury, or incision infection occurred. Imaging examinations at 2 days postoperatively showed that the α angle, LCE, and the distances from the femoral artery and vein to the acetabular rim significantly decreased when compared with preoperative values, while the offset value significantly increased, with all differences significant (P<0.05). All the 9 patients were followed up 22-45 months (mean, 35.0 months). During the follow-up, no recurrence of hip snapping was observed; hip pain, daily living ability and activity function were markedly improved. At last follow-up, the mHHS score, iHOT-12 score, VAS score, as well as hip external rotation muscle strength were all significantly improved when compared with preoperative values (P<0.05), but there was no significant difference in hip flexion strength between before and after operation (P>0.05). ConclusionArthroscopic iliopsoas tendon tenotomy at labral level complicated with internal snapping hip can effectively relieve the pain and snapping symptoms of iliopsoas cyst combined with medial snapping hip, and promote the recovery of hip function, which is a safe and effective minimally invasive operation.
Discipline construction is the core of hospital survival and development, and an important carrier for hospitals to show service ability and play social benefits. The practice of Ziyang Central Hospital shows that the group department operation service model, by bringing together operational, performance, medical, insurance, and clinical department staff into a team, led by a member of the party and government leadership, has a positive impact on the development of the discipline, and has achieved significant results. This paper summarizes and analyzes the group department operation service model at Ziyang Central Hospital, and proposes that this service model is a new pathway to promote discipline development and provides a new perspective and reference experience for the hospital to achieve business and finance integration.
