Objective To summarize and review the heterogeneity of bone marrow derived stem cells (BMDSCs) and its formation mechanism and significance, and to analyze the possible roles and mechanisms in intestinal epithel ial reconstruction. Methods The related l iterature about BMDSCs heterogeneity and its role in intestinal epithel ial repair was reviewed and analyzed. Results The heterogeneity of BMDSCs provided better explanations for its multi-potency. The probable mechanisms of BMDSCs to repair intestinal epithel ium included direct implantation into intestinal epithel ium, fusion between BMDSCs and intestinal stem cells, and promotion of injury microcirculation reconstruction. Conclusion BMDSCs have a bright future in gastrointestinal injury caused by inflammatory bowl disease and regeneration.
Myofibroblasts as key effector cells in fibrotic lesions, exhibit apoptosis resistance as a core factor contributing to the persistent progression and refractory reversal of fibrosis. This article systematically investigates their role in pulmonary fibrosis by focusing on the origin and regulation of myofibroblasts, the mechanisms underlying apoptosis resistance, and the association between cellular senescence and apoptosis resistance. Key analyses include the molecular regulatory network of apoptosis resistance, metabolic and epigenetic mechanisms, immune evasion pathways, and the regulatory effects of cellular senescence on apoptosis processes. These findings aim to provide novel insights for elucidating the pathogenesis of pulmonary fibrosis and guiding therapeutic drug development.
