Research progress of correlation between traumatic brain injury and fracture healing_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANG Chong , DENG Kai , GUO Yongchun , WANG Zhe ,  YU Guorong

Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan Hubei, 430071, P.R.China;

Corresponding?author：

YU Guorong, Email: yuguorong195505@126.com

Keywords：

Traumatic brain injury; fracture healing; mechanism

DOI：

10.7507/1002-1892.201612048

Video：

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Objective To review the current status and advances of the correlation between traumatic brain injury (TBI) and fracture healing. Methods The related domestic and abroad literature about the correlation between TBI and fracture healing was extensively reviewed and analyzed. Results There are a variety of studies on the correlation between TBI and fracture healing, which can be divided into two major aspects: revascularization and osteogenesis; the local and systemic changes of the neuropeptide and hormone after TBI. Conclusion TBI facilitates callus formation, the further research is needed to clarify the exact mechanism.

Citation： ZHANG Chong, DENG Kai, GUO Yongchun, WANG Zhe, YU Guorong. Research progress of correlation between traumatic brain injury and fracture healing. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(7): 885-889. doi: 10.7507/1002-1892.201612048 Copy

1.	Hu X, Zhang P, Xu Z, et al. GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem, 2013, 114(12): 2729-2737.
2.	Hinson HE, Rowell S, Schreiber M. Clinical evidence of inflammation driving secondary brain injury: a systematic review. J Trauma Acute Care Surg, 2015, 78(1): 184-191.
3.	Hofman M, Koopmans G, Kobbe P, et al. Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Mediators Inflamm, 2015, 2015: 204842.
4.	Helmy A, De Simoni MG, Guilfoyle MR, et al. Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury. Prog Neurobiol, 2011, 95(3): 352-372.
5.	Liu X, Zhou C, Li Y, et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One, 2013, 8(1): e54077.
6.	Boes M, Kain M, Kakar S, et al. Osteogenic effects of traumatic brain injury on experimental fracture-healing. J Bone Joint Surg (Am), 2006, 88(4): 738-743.
7.	Yang S, Ma Y, Liu Y, et al. Arachidonic acid: a bridge between traumatic brain injury and fracture healing. J Neurotrauma, 2012, 29(17): 2696-2705.
8.	Cadosch D, Gautschi OP, Thyer M, et al. Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury. J Bone Joint Surg (Am), 2009, 91(2): 282-288.
9.	Gautschi OP, Cadosch D, Frey SP, et al. Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg, 2009, 79(6): 449-455.
10.	Giannoudis PV, Mushtaq S, Harwood P, et al. Accelerated bone healing and excessive callus formation in patients with femoral fracture and head injury. Injury, 2006, 37 Suppl 3: S18-24.
11.	Wei Y, Wang L, Clark JC, et al. Elevated leptin expression in a rat model of fracture and traumatic brain injury. J Pharm Pharmacol, 2008, 60(12): 1667-1672.
12.	García-Castellano JM, Díaz-Herrera P, Morcuende JA. Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions. Iowa Orthop J, 2000, 20: 49-58.
13.	Hukkanen M, Konttinen YT, Santavirta S, et al. Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus. Clin Orthop Relat Res, 1995, 311(311): 247-257.
14.	Song Y, Bi L, Zhang Z, et al. Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Rep, 2012, 5(2): 432-438.
15.	Zhang D, Zhang P, Wang Y, et al. The influence of brain injury or peripheral nerve injury on calcitonin gene-related peptide concentration variation and fractures healing process. Artif Cells Blood Substit Immobil Biotechnol, 2009, 37(2): 85-91.
16.	Wang L, Yao X, Xiao L, et al. The effects of spinal cord injury on bone healing in patients with femoral fractures. J Spinal Cord Med, 2014, 37(4): 414-419.
17.	Yan H, Zhang HW, Fu P, et al. Leptin’s effect on accelerated fracture healing after traumatic brain injury. Neurol Res, 2013, 35(5): 537-544.
18.	李爭爭, 趙軍偉, 羅偉, 等. 神經氈蛋白-1 在創傷性顱腦損傷伴脛骨骨折愈合過程中的表達變化.中南大學學報: 醫學版, 2017, 42(2): 154-160.
19.	Fukuda T, Takeda S, Xu R, et al. Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013, 497(7450): 490-493.
20.	Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A. Nature, 2012, 485(7396): 69-74.
21.	李爭爭, 趙軍偉, 移志剛, 等. 腦信號蛋白 3A 在創傷性顱腦損傷伴脛骨骨折愈合過程中的表達變化. 中國修復重建外科雜志, 2016, 30(10): 1225-1232.
22.	Suzuki A, Uemura T, Nakamura H. Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration. Clin Calcium, 2010, 20(12): 1820-1827.
23.	Gu XC, Zhang XB, Hu B, et al. Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells. Neuropeptides, 2016, 60: 6061-6666.
24.	劉繼超, 孫驥, 李鈺龍. 肢體骨折合并腦外傷患者血清中 VEGF、PDGF 的變化. 生物骨科材料與臨床研究, 2016, 13(4): 52-54.
25.	陳雯輝, 王大業, 麻松, 等. 腦外傷后血小板衍生生長因子及血管內皮生長因子對骨折愈合影響的實驗研究. 首都醫科大學學報, 2008, 29(6): 745-753.
26.	田寶鵬, 陳雯輝, 潘海濤, 等. 腦外傷后胰島素樣生長因子-Ⅰ及血小板衍生生長因子對骨折愈合的影響. 首都醫科大學學報, 2008, 29(1): 69-73.
27.	Sang XG, Wang ZY, Qin T, et al. Elevated concentrations of hypoxia-inducible factor-1α in patients with fracture and concomitant traumatic brain injury. Ann Clin Biochem, 2016. [Epub ahead of print].
28.	徐林, 柏小金, 駱旭東, 等. 大鼠股骨骨折合并腦外傷時 HIF-1α 及 Cbfα1 的血清表達及意義. 臨床和實驗醫學雜志, 2014, 13(9): 689-692.
29.	Lolmède K, Durand de Saint Front V, Galitzky J, et al. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord, 2003, 27(10): 1187-1195.
30.	王守君, 張柳, 孫良智, 等. 大鼠股骨骨折合并腦外傷時骨愈合過程中 TGF-β₁ 的作用. 第四軍醫大學學報, 2006, 27(15): 1407-1410.
31.	梁春雨, 田發明, 張柳, 等. 顱腦損傷對骨折愈合中 BMP-2 和 VEGF 表達的影響. 中國煤炭工業醫學雜志, 2012, 15(11): 1761-1763.
32.	Li M, Ke HZ, Qi H, et al. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res, 2003, 18(11): 2033-2042.
33.	Niki Y, Takaishi H, Takito J, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J Immunol, 2007, 179(1): 639-646.
34.	鄭少濤, 林喜容, 周少鵬. 腦外傷合并骨折患者血清胰島素生長因子Ⅱ水平的變化. 中國現代醫生, 2014, 52(2): 19-20, 23.
35.	Zhuang YF, Li J. Serum EGF and NGF levels of patients with brain injury and limb fracture. Asian Pac J Trop Med, 2013, 6(5): 383-386.
36.	陳雅波, 吳珊鵬, 徐亞運, 等. 肢體骨折合并腦外傷神經元特異性烯醇化酶與骨痂生長的關系. 中華實驗外科雜志, 2016, 33(12): 2739-2740.
37.	湯俊君, 吳克儉, 張建, 等. 上皮鈣離子通道 TRPV6 在腦外傷合并骨折大鼠模型骨折部位表達的實驗研究. 臨床和實驗醫學雜志, 2015, 14(12): 961-964.

1. Hu X, Zhang P, Xu Z, et al. GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem, 2013, 114(12): 2729-2737.
2. Hinson HE, Rowell S, Schreiber M. Clinical evidence of inflammation driving secondary brain injury: a systematic review. J Trauma Acute Care Surg, 2015, 78(1): 184-191.
3. Hofman M, Koopmans G, Kobbe P, et al. Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Mediators Inflamm, 2015, 2015: 204842.
4. Helmy A, De Simoni MG, Guilfoyle MR, et al. Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury. Prog Neurobiol, 2011, 95(3): 352-372.
5. Liu X, Zhou C, Li Y, et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One, 2013, 8(1): e54077.
6. Boes M, Kain M, Kakar S, et al. Osteogenic effects of traumatic brain injury on experimental fracture-healing. J Bone Joint Surg (Am), 2006, 88(4): 738-743.
7. Yang S, Ma Y, Liu Y, et al. Arachidonic acid: a bridge between traumatic brain injury and fracture healing. J Neurotrauma, 2012, 29(17): 2696-2705.
8. Cadosch D, Gautschi OP, Thyer M, et al. Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury. J Bone Joint Surg (Am), 2009, 91(2): 282-288.
9. Gautschi OP, Cadosch D, Frey SP, et al. Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg, 2009, 79(6): 449-455.
10. Giannoudis PV, Mushtaq S, Harwood P, et al. Accelerated bone healing and excessive callus formation in patients with femoral fracture and head injury. Injury, 2006, 37 Suppl 3: S18-24.
11. Wei Y, Wang L, Clark JC, et al. Elevated leptin expression in a rat model of fracture and traumatic brain injury. J Pharm Pharmacol, 2008, 60(12): 1667-1672.
12. García-Castellano JM, Díaz-Herrera P, Morcuende JA. Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions. Iowa Orthop J, 2000, 20: 49-58.
13. Hukkanen M, Konttinen YT, Santavirta S, et al. Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus. Clin Orthop Relat Res, 1995, 311(311): 247-257.
14. Song Y, Bi L, Zhang Z, et al. Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Rep, 2012, 5(2): 432-438.
15. Zhang D, Zhang P, Wang Y, et al. The influence of brain injury or peripheral nerve injury on calcitonin gene-related peptide concentration variation and fractures healing process. Artif Cells Blood Substit Immobil Biotechnol, 2009, 37(2): 85-91.
16. Wang L, Yao X, Xiao L, et al. The effects of spinal cord injury on bone healing in patients with femoral fractures. J Spinal Cord Med, 2014, 37(4): 414-419.
17. Yan H, Zhang HW, Fu P, et al. Leptin’s effect on accelerated fracture healing after traumatic brain injury. Neurol Res, 2013, 35(5): 537-544.
18. 李爭爭, 趙軍偉, 羅偉, 等. 神經氈蛋白-1 在創傷性顱腦損傷伴脛骨骨折愈合過程中的表達變化.中南大學學報: 醫學版, 2017, 42(2): 154-160.
19. Fukuda T, Takeda S, Xu R, et al. Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013, 497(7450): 490-493.
20. Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A. Nature, 2012, 485(7396): 69-74.
21. 李爭爭, 趙軍偉, 移志剛, 等. 腦信號蛋白 3A 在創傷性顱腦損傷伴脛骨骨折愈合過程中的表達變化. 中國修復重建外科雜志, 2016, 30(10): 1225-1232.
22. Suzuki A, Uemura T, Nakamura H. Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration. Clin Calcium, 2010, 20(12): 1820-1827.
23. Gu XC, Zhang XB, Hu B, et al. Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells. Neuropeptides, 2016, 60: 6061-6666.
24. 劉繼超, 孫驥, 李鈺龍. 肢體骨折合并腦外傷患者血清中 VEGF、PDGF 的變化. 生物骨科材料與臨床研究, 2016, 13(4): 52-54.
25. 陳雯輝, 王大業, 麻松, 等. 腦外傷后血小板衍生生長因子及血管內皮生長因子對骨折愈合影響的實驗研究. 首都醫科大學學報, 2008, 29(6): 745-753.
26. 田寶鵬, 陳雯輝, 潘海濤, 等. 腦外傷后胰島素樣生長因子-Ⅰ及血小板衍生生長因子對骨折愈合的影響. 首都醫科大學學報, 2008, 29(1): 69-73.
27. Sang XG, Wang ZY, Qin T, et al. Elevated concentrations of hypoxia-inducible factor-1α in patients with fracture and concomitant traumatic brain injury. Ann Clin Biochem, 2016. [Epub ahead of print].
28. 徐林, 柏小金, 駱旭東, 等. 大鼠股骨骨折合并腦外傷時 HIF-1α 及 Cbfα1 的血清表達及意義. 臨床和實驗醫學雜志, 2014, 13(9): 689-692.
29. Lolmède K, Durand de Saint Front V, Galitzky J, et al. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord, 2003, 27(10): 1187-1195.
30. 王守君, 張柳, 孫良智, 等. 大鼠股骨骨折合并腦外傷時骨愈合過程中 TGF-β₁ 的作用. 第四軍醫大學學報, 2006, 27(15): 1407-1410.
31. 梁春雨, 田發明, 張柳, 等. 顱腦損傷對骨折愈合中 BMP-2 和 VEGF 表達的影響. 中國煤炭工業醫學雜志, 2012, 15(11): 1761-1763.
32. Li M, Ke HZ, Qi H, et al. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res, 2003, 18(11): 2033-2042.
33. Niki Y, Takaishi H, Takito J, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J Immunol, 2007, 179(1): 639-646.
34. 鄭少濤, 林喜容, 周少鵬. 腦外傷合并骨折患者血清胰島素生長因子Ⅱ水平的變化. 中國現代醫生, 2014, 52(2): 19-20, 23.
35. Zhuang YF, Li J. Serum EGF and NGF levels of patients with brain injury and limb fracture. Asian Pac J Trop Med, 2013, 6(5): 383-386.
36. 陳雅波, 吳珊鵬, 徐亞運, 等. 肢體骨折合并腦外傷神經元特異性烯醇化酶與骨痂生長的關系. 中華實驗外科雜志, 2016, 33(12): 2739-2740.
37. 湯俊君, 吳克儉, 張建, 等. 上皮鈣離子通道 TRPV6 在腦外傷合并骨折大鼠模型骨折部位表達的實驗研究. 臨床和實驗醫學雜志, 2015, 14(12): 961-964.

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