巨噬細胞對急性肺損傷后炎癥的消解與組織修復的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

何園 ¹ , 張硌 ² ,  劉慧瑩 ¹ ,  柏長青 ¹

1. ;
2. ;

Corresponding?author：

劉慧瑩, Email: liuhuiying1982@sina.com; 柏長青, Email: baicq307@163.com

Keywords：

DOI：

10.7507/1671-6205.201711021

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Citation： 何園, 張硌, 劉慧瑩, 柏長青. 巨噬細胞對急性肺損傷后炎癥的消解與組織修復的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(4): 430-434. doi: 10.7507/1671-6205.201711021 Copy

1.	Dushianthan A, Grocott MP, Postle AD, et al. Acute respiratory distress syndrome and acute lung injury. Postgrad Med J, 2011, 87(1031): 612-622.
2.	韓李念, 陳旭林. 巨噬細胞在急性肺損傷的作用. 中華損傷與修復雜志(電子版), 2016, 11(4): 294-297.
3.	馬曉春, 王辰, 方強, 等. 急性肺損傷/急性呼吸窘迫綜合征診斷和治療指南(2006). 中華危重病急救醫學, 2006, 16(12): 1-6.
4.	任志慧, 章志丹, 穆恩, 等. 急性肺損傷/急性呼吸窘迫綜合征的流行病學調查分析. 中華醫學會第五次全國重癥醫學大會論文匯編, 2011.
5.	錢桂生. 急性肺損傷和急性呼吸窘迫綜合征的診斷與治療. 解放軍醫學雜志, 2009, 34(4): 371-373.
6.	Liu Q, Li W, Zeng QS, et al. Lung stress and strain during mechanical ventilation in animals with and without pulmonary acute respiratory distress syndrome. J Surg Res, 2013, 181(2): 300-307.
7.	Ricard JD, Dreyfuss D, Saumon G. Ventilator-induced lung injury. Curr Opin Crit Care, 2013, 369(22): 2126-2136.
8.	張偉, 蔣耀光, 李磊. 肺泡巨噬細胞與急性肺損傷. 創傷外科雜志, 2003, 5(5): 389-391.
9.	Serhan CN, Nan C, Dyke TEV. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol, 2008, 8(5): 349-361.
10.	Funk CD. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science, 2001, 294(5548): 1871-1875.
11.	張蓉, 章怡葦, 汪燕, 等. 脂氧素在急性肺損傷中作用及機制的研究進展. 上海交通大學學報(醫學版), 2016, 36(6): 926-929.
12.	Nan C, Serhan CN, Dahlén SE, et al. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev, 2006, 58(3): 463-487.
13.	Maderna P, Cottell DC, Berlasconi G, et al. Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of Rho GTPases. Am J Pathol, 2002, 160(6): 2275-2283.
14.	Freire-De-Lima CG, Xiao YQ, Gardai SJ, et al. Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem, 2006, 281(50): 38376-38384.
15.	陶慧嫻, 吳升華. 消散素與保護素. 生命的化學, 2009, 29(4): 604-608.
16.	Arita M, Ohira T, Sun YP, et al. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol, 2007, 178(6): 3912-3917.
17.	Schwab JM, Chiang N, Arita M, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature, 2007, 447(7146): 869-874.
18.	Williams A E, José RJ, Mercer PF, et al. Evidence for chemokine synergy during neutrophil migration in ARDS. Thorax, 2017, 72(1): 66-73.
19.	劉相良, 原銘貞, 劉笑玎, 等. 趨化因子及其受體在急性肺損傷中作用的研究進展. 吉林大學學報(醫學版), 2014(4): 908-912.
20.	Romanini J, Mielcke TR, Leal PC, et al. The role of CXCR2 chemokine receptors in the oral squamous cell carcinoma. Invest New Drug, 2012, 30(4): 1371.
21.	Konrad FM, Reutershan J. CXCR2 in acute lung injury. Mediators Inflamm, 2012: 740987.
22.	Kuboki S, Shin T, Huber N, et al. Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice. Hepatology, 2008, 48(4): 1213-1223.
23.	Herold S, Tabar TS, Janssen H, et al. Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia. Am J Respir Crit Care Med, 2011, 183(10): 1380-1390.
24.	Cakarova L, Marsh LM, Wilhelm J, et al. Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair. Am J Respir Crit Care Med, 2009, 180(6): 521-532.
25.	Jm VDB, Weyer S, Weening JJ, et al. Divergent effects of tumor necrosis factor alpha on apoptosis of human neutrophils. J Leukoc Biol, 2001, 69(3): 467-473.
26.	王炯, 黃維琳, 汪誠, 等. 巨噬細胞吞噬凋亡中性粒細胞及吞噬誘導巨噬細胞死亡的實時動態觀察. 中國科學(生命科學), 2014, 44(6): 571-577.
27.	Litvack ML, Palaniyar N. Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation. Innate Immun, 2010, 16(3): 191-200.
28.	Voll RE, Herrmann M, Roth EA, et al. Immunosuppressive effects of apoptotic cells. Nature, 1997, 390(6658): 350-351.
29.	Medeiros AI, Serezani CH, Sang PL, et al. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med, 2009, 206(1): 61-68.
30.	Golpon HA, Fadok VA, Tarasevicienestewart L, et al. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. Faseb J, 2004, 18(14): 1716-1718.
31.	Amano H, Morimoto K, Senba M, et al. Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia. J Immunol, 2004, 172(1): 398-409.
32.	Fadok VA, Bratton DL, Konowal A, et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest, 1998, 101(4): 890-898.
33.	Patel VA, Longacre AK, Fan H, et al. Apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic cells: implications for the delayed clearance model of autoimmunity. J Biol Chem, 2006, 281(8): 4663-4670.
34.	童曉鵬, 門連超, 張群輝. 基于巨噬細胞可塑性的分類研究. 現代免疫學, 2016(2): 130-136.
35.	屠國偉, 任楊華, 史懿, 等. 肺泡巨噬細胞亞型與急性肺損傷. 中國臨床醫學, 2017, 24(3): 470-475.
36.	Serbina NV, Jia T, Hohl TM, et al. Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol, 2008, 26(1): 421-452.
37.	張硌, 王義武, 張令強, 等. 巨噬細胞極性及調控機制. 科學通報, 2012(28): 2661-2665.
38.	Fleetwood AJ, Dinh H, Cook AD, et al. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J Leukoc Biol, 2009, 86(2): 411-421.
39.	Zhang P, Zhou C, Cheng L, et al. PLEKHO2 is essential for M-CSF-dependent macrophage survival. Cell Signal, 2017, 37: 115.
40.	盧惠倫, 刁振華, 陳培芬, 等. 肺泡巨噬細胞極化加劇內毒素性急性肺損傷的機制研究. 現代醫院, 2017, 17(8): 1182-1185.
41.	Xu H, Zhu J, Smith S, et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol, 2012, 13(7): 642.
42.	Morrison TJ, Jackson MV, Cunningham EK, et al. Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrialtransfer. Am J Respir Crit Care Med, 2017, 196(10): 1275-1286.
43.	孔祥歆, 劉卉芳, 陳鳳玲. CaMKKβ 通過激活 AMPK/JAK2/STAT3 信號促進小鼠單核巨噬細胞向 M2 表型轉換. 上海交通大學學報(醫學版), 2017, 37(7): 914-923.
44.	王保健, 毛旭. 槲皮素通過抑制肺巨噬細胞的 M1 極化減輕海水吸入誘導的小鼠急性肺損傷. 細胞與分子免疫學雜志, 2017, 33(6): 751-755.
45.	Wissinger E, Goulding J, Hussell T. Immune homeostasis in the respiratory tract and its impact on heterologous infection. Semin Immunol, 2009, 21(3): 147-155.
46.	Snelgrove RJ, Goulding J, Didierlaurent AM, et al. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol, 2008, 9(9): 1074.
47.	Rock JR, Hogan BLM. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu Rev Cell Dev Biol, 2011, 27: 493-512.
48.	Bosurgi L, Cao YG, Cabezacabrerizo M, et al. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science, 2017, 356(6342): 1072-1076.
49.	Ganter MT, Roux J, Miyazawa B, et al. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res, 2008, 102(7): 804-812.
50.	Terakado M, Gon Y, Sekiyama A, et al. The Rac1/JNK pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol, 2011, 300(1): L56-L63.
51.	Tighe RM, Liang J, Liu N, et al. Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. Am J Respir Cell Mol biol, 2011, 45(4): 781-788.
52.	張彥偉, 陳純. 巨噬細胞參與肺纖維化的相關研究進展. 海峽藥學, 2017, 29(5): 8-12.
53.	Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol, 2011, 11(11): 723-737.

1. Dushianthan A, Grocott MP, Postle AD, et al. Acute respiratory distress syndrome and acute lung injury. Postgrad Med J, 2011, 87(1031): 612-622.
2. 韓李念, 陳旭林. 巨噬細胞在急性肺損傷的作用. 中華損傷與修復雜志(電子版), 2016, 11(4): 294-297.
3. 馬曉春, 王辰, 方強, 等. 急性肺損傷/急性呼吸窘迫綜合征診斷和治療指南(2006). 中華危重病急救醫學, 2006, 16(12): 1-6.
4. 任志慧, 章志丹, 穆恩, 等. 急性肺損傷/急性呼吸窘迫綜合征的流行病學調查分析. 中華醫學會第五次全國重癥醫學大會論文匯編, 2011.
5. 錢桂生. 急性肺損傷和急性呼吸窘迫綜合征的診斷與治療. 解放軍醫學雜志, 2009, 34(4): 371-373.
6. Liu Q, Li W, Zeng QS, et al. Lung stress and strain during mechanical ventilation in animals with and without pulmonary acute respiratory distress syndrome. J Surg Res, 2013, 181(2): 300-307.
7. Ricard JD, Dreyfuss D, Saumon G. Ventilator-induced lung injury. Curr Opin Crit Care, 2013, 369(22): 2126-2136.
8. 張偉, 蔣耀光, 李磊. 肺泡巨噬細胞與急性肺損傷. 創傷外科雜志, 2003, 5(5): 389-391.
9. Serhan CN, Nan C, Dyke TEV. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol, 2008, 8(5): 349-361.
10. Funk CD. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science, 2001, 294(5548): 1871-1875.
11. 張蓉, 章怡葦, 汪燕, 等. 脂氧素在急性肺損傷中作用及機制的研究進展. 上海交通大學學報(醫學版), 2016, 36(6): 926-929.
12. Nan C, Serhan CN, Dahlén SE, et al. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev, 2006, 58(3): 463-487.
13. Maderna P, Cottell DC, Berlasconi G, et al. Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of Rho GTPases. Am J Pathol, 2002, 160(6): 2275-2283.
14. Freire-De-Lima CG, Xiao YQ, Gardai SJ, et al. Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem, 2006, 281(50): 38376-38384.
15. 陶慧嫻, 吳升華. 消散素與保護素. 生命的化學, 2009, 29(4): 604-608.
16. Arita M, Ohira T, Sun YP, et al. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol, 2007, 178(6): 3912-3917.
17. Schwab JM, Chiang N, Arita M, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature, 2007, 447(7146): 869-874.
18. Williams A E, José RJ, Mercer PF, et al. Evidence for chemokine synergy during neutrophil migration in ARDS. Thorax, 2017, 72(1): 66-73.
19. 劉相良, 原銘貞, 劉笑玎, 等. 趨化因子及其受體在急性肺損傷中作用的研究進展. 吉林大學學報(醫學版), 2014(4): 908-912.
20. Romanini J, Mielcke TR, Leal PC, et al. The role of CXCR2 chemokine receptors in the oral squamous cell carcinoma. Invest New Drug, 2012, 30(4): 1371.
21. Konrad FM, Reutershan J. CXCR2 in acute lung injury. Mediators Inflamm, 2012: 740987.
22. Kuboki S, Shin T, Huber N, et al. Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice. Hepatology, 2008, 48(4): 1213-1223.
23. Herold S, Tabar TS, Janssen H, et al. Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia. Am J Respir Crit Care Med, 2011, 183(10): 1380-1390.
24. Cakarova L, Marsh LM, Wilhelm J, et al. Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair. Am J Respir Crit Care Med, 2009, 180(6): 521-532.
25. Jm VDB, Weyer S, Weening JJ, et al. Divergent effects of tumor necrosis factor alpha on apoptosis of human neutrophils. J Leukoc Biol, 2001, 69(3): 467-473.
26. 王炯, 黃維琳, 汪誠, 等. 巨噬細胞吞噬凋亡中性粒細胞及吞噬誘導巨噬細胞死亡的實時動態觀察. 中國科學(生命科學), 2014, 44(6): 571-577.
27. Litvack ML, Palaniyar N. Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation. Innate Immun, 2010, 16(3): 191-200.
28. Voll RE, Herrmann M, Roth EA, et al. Immunosuppressive effects of apoptotic cells. Nature, 1997, 390(6658): 350-351.
29. Medeiros AI, Serezani CH, Sang PL, et al. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med, 2009, 206(1): 61-68.
30. Golpon HA, Fadok VA, Tarasevicienestewart L, et al. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. Faseb J, 2004, 18(14): 1716-1718.
31. Amano H, Morimoto K, Senba M, et al. Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia. J Immunol, 2004, 172(1): 398-409.
32. Fadok VA, Bratton DL, Konowal A, et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest, 1998, 101(4): 890-898.
33. Patel VA, Longacre AK, Fan H, et al. Apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic cells: implications for the delayed clearance model of autoimmunity. J Biol Chem, 2006, 281(8): 4663-4670.
34. 童曉鵬, 門連超, 張群輝. 基于巨噬細胞可塑性的分類研究. 現代免疫學, 2016(2): 130-136.
35. 屠國偉, 任楊華, 史懿, 等. 肺泡巨噬細胞亞型與急性肺損傷. 中國臨床醫學, 2017, 24(3): 470-475.
36. Serbina NV, Jia T, Hohl TM, et al. Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol, 2008, 26(1): 421-452.
37. 張硌, 王義武, 張令強, 等. 巨噬細胞極性及調控機制. 科學通報, 2012(28): 2661-2665.
38. Fleetwood AJ, Dinh H, Cook AD, et al. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J Leukoc Biol, 2009, 86(2): 411-421.
39. Zhang P, Zhou C, Cheng L, et al. PLEKHO2 is essential for M-CSF-dependent macrophage survival. Cell Signal, 2017, 37: 115.
40. 盧惠倫, 刁振華, 陳培芬, 等. 肺泡巨噬細胞極化加劇內毒素性急性肺損傷的機制研究. 現代醫院, 2017, 17(8): 1182-1185.
41. Xu H, Zhu J, Smith S, et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol, 2012, 13(7): 642.
42. Morrison TJ, Jackson MV, Cunningham EK, et al. Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrialtransfer. Am J Respir Crit Care Med, 2017, 196(10): 1275-1286.
43. 孔祥歆, 劉卉芳, 陳鳳玲. CaMKKβ 通過激活 AMPK/JAK2/STAT3 信號促進小鼠單核巨噬細胞向 M2 表型轉換. 上海交通大學學報(醫學版), 2017, 37(7): 914-923.
44. 王保健, 毛旭. 槲皮素通過抑制肺巨噬細胞的 M1 極化減輕海水吸入誘導的小鼠急性肺損傷. 細胞與分子免疫學雜志, 2017, 33(6): 751-755.
45. Wissinger E, Goulding J, Hussell T. Immune homeostasis in the respiratory tract and its impact on heterologous infection. Semin Immunol, 2009, 21(3): 147-155.
46. Snelgrove RJ, Goulding J, Didierlaurent AM, et al. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol, 2008, 9(9): 1074.
47. Rock JR, Hogan BLM. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu Rev Cell Dev Biol, 2011, 27: 493-512.
48. Bosurgi L, Cao YG, Cabezacabrerizo M, et al. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science, 2017, 356(6342): 1072-1076.
49. Ganter MT, Roux J, Miyazawa B, et al. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res, 2008, 102(7): 804-812.
50. Terakado M, Gon Y, Sekiyama A, et al. The Rac1/JNK pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol, 2011, 300(1): L56-L63.
51. Tighe RM, Liang J, Liu N, et al. Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. Am J Respir Cell Mol biol, 2011, 45(4): 781-788.
52. 張彥偉, 陳純. 巨噬細胞參與肺纖維化的相關研究進展. 海峽藥學, 2017, 29(5): 8-12.
53. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol, 2011, 11(11): 723-737.

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巨噬細胞對急性肺損傷后炎癥的消解與組織修復的研究進展

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