降鈣素原在肺部感染診治中的價值_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

王健珍 ,  曹大偉 , 張新日

山西醫科大學第一醫院呼吸與危重癥醫學科（山西太原 030001）;

Corresponding?author：

曹大偉, Email: caodawei0358@163.com

Keywords：

DOI：

10.7507/1671-6205.201801019

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Citation： 王健珍, 曹大偉, 張新日. 降鈣素原在肺部感染診治中的價值. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(4): 435-438. doi: 10.7507/1671-6205.201801019 Copy

1.	Becker KL, Nylén ES, White JC, et al. Clinical review 167: procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab, 2004, 89(4): 1512.
2.	Alnakeeb S, Clermont G. Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections. Crit Care, 2005, 9(3): 1-2.
3.	Russwurm S, Stonans I, Stonane E, et al. Procalcitonin and CGRP-1 mrna expression in various human tissues. Shock, 2001, 16(2): 109.
4.	Linscheid P, Seboek D, Nylen ES, et al. In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinology, 2003, 144(12): 5578-5584.
5.	Linscheid P, Seboek D, Schaer DJ, et al. Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Criti Care Med, 2004, 32(8): 1715.
6.	Müller B, White JC, Nylén ES, et al. Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab, 2001, 86(1): 396.
7.	Hatzistilianou M. Diagnostic and prognostic role of procalcitonin in infections. ScientificWorldJournal, 2010, 10(1): 1941-1946.
8.	Meisner M, Lohs T, Huettemann E, et al. The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function. Eur J Anaesthesiol., 2001, 18(2): 79-87.
9.	張德文, 劉勇, 龍林會, 童玲. 血清 PCT 檢測對慢性腎衰竭患者合并細菌感染的臨床應用價值. 實用醫院臨床雜志, 2017, 14(03): 59-61.
10.	陶瑾, 申新宏, 艾永紅, 等. 血清 PCT 在患者腹膜透析感染性腹膜炎中的診斷價值. 中華醫院感染學雜志, 2015, 25(16): 3610-3612.
11.	高慧, 呂利明, 張曉華, 等. 透析感染患者血漿 PCT 和 C-反應蛋白的比較研究. 中華醫院感染學雜志, 2016, 26(19): 4404-4406.
12.	Tavares E, Mi?ano FJ. Immunoneutralization of the aminoprocalcitonin peptide of procalcitonin protects rats from lethal endotoxaemia: neuroendocrine and systemic studies. Clin Sci (Lond), 2010, 119(12): 519-534.
13.	Sexton PM, Christopoulos G, Christopoulos A, et al. Procalcitonin has bioactivity at calcitonin receptor family complexes: potential mediator implications in sepsis. Crit Care Med, 2008, 36(36): 1637-1640.
14.	Araujo M, DoiSQ, Palant CE, et al. Procalcitonin induced cytotoxicity and apoptosis in mesangial cells: implications for septic renal injury. Inflamm Res, 2013, 62(10): 887-894.
15.	van Vugt SF, Broekhuizen BD, Lammens C, et al. Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ 2013, 346(30): f2450.
16.	Holm A, Pedersen SS, Nexoe J, et al. Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care. Br J Gen Pract, 2007, 57(540): 555-560.
17.	Andreeva E, Melbye H. Usefulness of C-reactive protein testing in acute cough/respiratory tract infection: an open cluster-randomized clinical trial with C-reactive protein testing in the intervention group. BMC Fam Pract, 2014, 15(1): 80.
18.	尹義平, 胡蘇萍, 楊澄清, 等. PCT 在細菌性肺炎及肺結核中的鑒別研究. 臨床肺科雜志, 2013, 18(5): 786-788.
19.	Haeuptle J, Zaborsky R, Fiumefreddo R, et al. Prognostic value of procalcitonin in Legionella pneumonia. Eur J Clin Microbiol Infect Dis, 2009, 28(1): 55-60.
20.	李艷紅, 張霞, 郭秋野. C 反應蛋白聯合 PCT 檢測在老年社區獲得性肺炎中應用 126 例臨床觀察. 實用臨床醫藥雜志, 2012, 16(17): 135-137.
21.	Wu CW, Wu JY, Chen CK, et al. Does procalcitonin, C-reactive protein, or interleukin-6 test have a role in the diagnosis of severe infection in patients with febrile neutropenia? A systematic review and meta-analysis. Support Care Cancer, 2015, 23(10): 2863-2872.
22.	向攀, 趙紅心, 王芳, 等. 腎綜合征出血熱患者 PCT 測定的臨床價值中華實驗和臨床感染病雜志: 電子版, 2015, 9(6): 28-30.
23.	Jereb M, Luna?ek NK, Kotar T, et al. Procalcitonin in hantavirus infections. Scand J Clin Lab Inves, 2011, 71(4): 287-291.
24.	Hoenigl M, Raggam RB, Wagner J, et al. Procalcitonin fails to predict bacteremia in SIRS patients: a cohort study. Int J Clin Pract, 2014, 68(10): 1278-1281.
25.	Yu Y, Li XX, Jiang LX, et al. Procalcitonin levels in patients with positive blood culture, positive body fluid culture, sepsis, and severe sepsis: a cross-sectional study. Infect Dis, 2016, 48(1): 63-69.
26.	Riedel S, Melendez JH, An AT, et al. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am J Clin Pathol, 2011, 135(2): 182-189.
27.	Zhao Y, Li C, Jia Y. Evaluation of the Mortality in Emergency Department Sepsis score combined with procalcitonin in septic patients. Am J Emerg Med, 2013, 31(7): 1086.
28.	韓忠學, 劉靜, 鞏靜. 降鈣素原在鮑曼不動桿菌定植與感染鑒別中的應用. 國際檢驗醫學雜志, 2017, 38(3): 407-408.
29.	任紅梅. 血清炎性指標對血流感染患者感染病原菌早期鑒別診斷的價值. 國際檢驗醫學雜志, 2016, 37(10): 1373-1374.
30.	Guo S Y, Zhou Y, Hu Q F, et al. Procalcitonin is a marker of gram-negative bacteremia in patients with sepsis. Am J Med Sci, 2015, 349(6): 499-504.
31.	Maisel A, Neath S X, Landsberg J, et al. Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: results from the BACH (Biomarkers in Acute Heart Failure) trial. Eur J Heart Fail, 2012, 14(3): 278-286.
32.	Demissei BG, Cleland JG, O'Connor CM, et al. Procalcitonin-based indication of bacterial infection identifies high risk acute heart failure patients. Int J Cardiol, 2016, 204: 164-171.
33.	Schuetz P, Kutz A, Grolimund E, et al. Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: results from the randomized ProHOSP trial. Int J Cardiol, 2014, 175(3): 464-472.
34.	Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections Eur Respir J, 2011, 17 Suppl 6(s6): 1.
35.	PCT 急診臨床應用專家共識組. PCT(PCT) 急診臨床應用的專家共識. 中華急診醫學雜志, 2012, 21(9): 944-951.
36.	Schuetz P, Wirz Y, Sager R, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev, 2017, 10: CD007498.
37.	Nora D, Salluh J, Martin-Loeches I, et al. Biomarker-guided antibiotic therapy-strengths and limitations. Ann Transl Med, 2017, 5(10): 208.
38.	Dusemund F, Bucher B, Meyer S, et al. Influence of procalcitonin on decision to start antibiotic treatment in patients with a lower respiratory tract infection: insight from the observational multicentric ProREAL surveillance. Eur J Clin Microbiol Infect Dis, 2013, 32(1): 51-60.
39.	Balk R A, Bozzette S A, Cao Z, et al. Effect of Procalcitonin Testing on Healthcare Utilization and Costs in Critically Ill Patients in the United States. Chest, 2016, 151(1).
40.	Caspar C, Markus F, Andreas F B, et al. Point-of-care procalcitonin test to reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD. Int J Chron Obstruct Pulmon Dis, 2016, 11(Issue 1): 1381-1389.
41.	Kasamatsu Y, Yamaguchi T, Kawaguchi T, et al. Usefulness of a semi-quantitative procalcitonin test and the A-DROP Japanese prognostic scale for predicting mortality among adults hospitalized with community-acquired pneumonia. Respirology, 2012, 17(2): 330-336.
42.	Schuetz P, Suterwidmer I, Chaudri A, et al. Prognostic value of procalcitonin in community-acquired pneumonia. Eur Respir J, 2011, 37(2): 384-392.
43.	徐沖, 董麗霞, 曹潔. PCT 在社區獲得性肺炎預后評估中的價值. 中國呼吸與危重監護雜志, 2017(2): 117-121.
44.	Wacker C, Prkno A, Brunkhorst FM, et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis, 2013, 13(5): 426-435.
45.	Schuetz P, Raad I, Amin DN. Using procalcitonin-guided algorithms to improve antimicrobial therapy in ICU patients with respiratory infections and sepsis. Curr Opin Crit Care, 2013, 19(5): 453-460.

1. Becker KL, Nylén ES, White JC, et al. Clinical review 167: procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab, 2004, 89(4): 1512.
2. Alnakeeb S, Clermont G. Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections. Crit Care, 2005, 9(3): 1-2.
3. Russwurm S, Stonans I, Stonane E, et al. Procalcitonin and CGRP-1 mrna expression in various human tissues. Shock, 2001, 16(2): 109.
4. Linscheid P, Seboek D, Nylen ES, et al. In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinology, 2003, 144(12): 5578-5584.
5. Linscheid P, Seboek D, Schaer DJ, et al. Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Criti Care Med, 2004, 32(8): 1715.
6. Müller B, White JC, Nylén ES, et al. Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab, 2001, 86(1): 396.
7. Hatzistilianou M. Diagnostic and prognostic role of procalcitonin in infections. ScientificWorldJournal, 2010, 10(1): 1941-1946.
8. Meisner M, Lohs T, Huettemann E, et al. The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function. Eur J Anaesthesiol., 2001, 18(2): 79-87.
9. 張德文, 劉勇, 龍林會, 童玲. 血清 PCT 檢測對慢性腎衰竭患者合并細菌感染的臨床應用價值. 實用醫院臨床雜志, 2017, 14(03): 59-61.
10. 陶瑾, 申新宏, 艾永紅, 等. 血清 PCT 在患者腹膜透析感染性腹膜炎中的診斷價值. 中華醫院感染學雜志, 2015, 25(16): 3610-3612.
11. 高慧, 呂利明, 張曉華, 等. 透析感染患者血漿 PCT 和 C-反應蛋白的比較研究. 中華醫院感染學雜志, 2016, 26(19): 4404-4406.
12. Tavares E, Mi?ano FJ. Immunoneutralization of the aminoprocalcitonin peptide of procalcitonin protects rats from lethal endotoxaemia: neuroendocrine and systemic studies. Clin Sci (Lond), 2010, 119(12): 519-534.
13. Sexton PM, Christopoulos G, Christopoulos A, et al. Procalcitonin has bioactivity at calcitonin receptor family complexes: potential mediator implications in sepsis. Crit Care Med, 2008, 36(36): 1637-1640.
14. Araujo M, DoiSQ, Palant CE, et al. Procalcitonin induced cytotoxicity and apoptosis in mesangial cells: implications for septic renal injury. Inflamm Res, 2013, 62(10): 887-894.
15. van Vugt SF, Broekhuizen BD, Lammens C, et al. Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ 2013, 346(30): f2450.
16. Holm A, Pedersen SS, Nexoe J, et al. Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care. Br J Gen Pract, 2007, 57(540): 555-560.
17. Andreeva E, Melbye H. Usefulness of C-reactive protein testing in acute cough/respiratory tract infection: an open cluster-randomized clinical trial with C-reactive protein testing in the intervention group. BMC Fam Pract, 2014, 15(1): 80.
18. 尹義平, 胡蘇萍, 楊澄清, 等. PCT 在細菌性肺炎及肺結核中的鑒別研究. 臨床肺科雜志, 2013, 18(5): 786-788.
19. Haeuptle J, Zaborsky R, Fiumefreddo R, et al. Prognostic value of procalcitonin in Legionella pneumonia. Eur J Clin Microbiol Infect Dis, 2009, 28(1): 55-60.
20. 李艷紅, 張霞, 郭秋野. C 反應蛋白聯合 PCT 檢測在老年社區獲得性肺炎中應用 126 例臨床觀察. 實用臨床醫藥雜志, 2012, 16(17): 135-137.
21. Wu CW, Wu JY, Chen CK, et al. Does procalcitonin, C-reactive protein, or interleukin-6 test have a role in the diagnosis of severe infection in patients with febrile neutropenia? A systematic review and meta-analysis. Support Care Cancer, 2015, 23(10): 2863-2872.
22. 向攀, 趙紅心, 王芳, 等. 腎綜合征出血熱患者 PCT 測定的臨床價值中華實驗和臨床感染病雜志: 電子版, 2015, 9(6): 28-30.
23. Jereb M, Luna?ek NK, Kotar T, et al. Procalcitonin in hantavirus infections. Scand J Clin Lab Inves, 2011, 71(4): 287-291.
24. Hoenigl M, Raggam RB, Wagner J, et al. Procalcitonin fails to predict bacteremia in SIRS patients: a cohort study. Int J Clin Pract, 2014, 68(10): 1278-1281.
25. Yu Y, Li XX, Jiang LX, et al. Procalcitonin levels in patients with positive blood culture, positive body fluid culture, sepsis, and severe sepsis: a cross-sectional study. Infect Dis, 2016, 48(1): 63-69.
26. Riedel S, Melendez JH, An AT, et al. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am J Clin Pathol, 2011, 135(2): 182-189.
27. Zhao Y, Li C, Jia Y. Evaluation of the Mortality in Emergency Department Sepsis score combined with procalcitonin in septic patients. Am J Emerg Med, 2013, 31(7): 1086.
28. 韓忠學, 劉靜, 鞏靜. 降鈣素原在鮑曼不動桿菌定植與感染鑒別中的應用. 國際檢驗醫學雜志, 2017, 38(3): 407-408.
29. 任紅梅. 血清炎性指標對血流感染患者感染病原菌早期鑒別診斷的價值. 國際檢驗醫學雜志, 2016, 37(10): 1373-1374.
30. Guo S Y, Zhou Y, Hu Q F, et al. Procalcitonin is a marker of gram-negative bacteremia in patients with sepsis. Am J Med Sci, 2015, 349(6): 499-504.
31. Maisel A, Neath S X, Landsberg J, et al. Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: results from the BACH (Biomarkers in Acute Heart Failure) trial. Eur J Heart Fail, 2012, 14(3): 278-286.
32. Demissei BG, Cleland JG, O'Connor CM, et al. Procalcitonin-based indication of bacterial infection identifies high risk acute heart failure patients. Int J Cardiol, 2016, 204: 164-171.
33. Schuetz P, Kutz A, Grolimund E, et al. Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: results from the randomized ProHOSP trial. Int J Cardiol, 2014, 175(3): 464-472.
34. Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections Eur Respir J, 2011, 17 Suppl 6(s6): 1.
35. PCT 急診臨床應用專家共識組. PCT(PCT) 急診臨床應用的專家共識. 中華急診醫學雜志, 2012, 21(9): 944-951.
36. Schuetz P, Wirz Y, Sager R, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev, 2017, 10: CD007498.
37. Nora D, Salluh J, Martin-Loeches I, et al. Biomarker-guided antibiotic therapy-strengths and limitations. Ann Transl Med, 2017, 5(10): 208.
38. Dusemund F, Bucher B, Meyer S, et al. Influence of procalcitonin on decision to start antibiotic treatment in patients with a lower respiratory tract infection: insight from the observational multicentric ProREAL surveillance. Eur J Clin Microbiol Infect Dis, 2013, 32(1): 51-60.
39. Balk R A, Bozzette S A, Cao Z, et al. Effect of Procalcitonin Testing on Healthcare Utilization and Costs in Critically Ill Patients in the United States. Chest, 2016, 151(1).
40. Caspar C, Markus F, Andreas F B, et al. Point-of-care procalcitonin test to reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD. Int J Chron Obstruct Pulmon Dis, 2016, 11(Issue 1): 1381-1389.
41. Kasamatsu Y, Yamaguchi T, Kawaguchi T, et al. Usefulness of a semi-quantitative procalcitonin test and the A-DROP Japanese prognostic scale for predicting mortality among adults hospitalized with community-acquired pneumonia. Respirology, 2012, 17(2): 330-336.
42. Schuetz P, Suterwidmer I, Chaudri A, et al. Prognostic value of procalcitonin in community-acquired pneumonia. Eur Respir J, 2011, 37(2): 384-392.
43. 徐沖, 董麗霞, 曹潔. PCT 在社區獲得性肺炎預后評估中的價值. 中國呼吸與危重監護雜志, 2017(2): 117-121.
44. Wacker C, Prkno A, Brunkhorst FM, et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis, 2013, 13(5): 426-435.
45. Schuetz P, Raad I, Amin DN. Using procalcitonin-guided algorithms to improve antimicrobial therapy in ICU patients with respiratory infections and sepsis. Curr Opin Crit Care, 2013, 19(5): 453-460.

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降鈣素原在肺部感染診治中的價值

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