【摘要】 目的 探討結膜惡性黑色素瘤的手術治療方法。 方法 1997年1月-2007年1月收治結膜惡性黑色素瘤48例，均為單眼。腫瘤范圍:lt;1/3眼瞼長度及結膜14例，gt;1/3眼瞼長度，部分穹隆結膜受累19例，上下眼瞼及內外眥大部分結膜受累者15例。采用單純腫瘤切除術、單純腫瘤切除聯合液氮冷凍治療、眼眶內容物剜除術3種治療方法。 結果 所有患者均經病理學證實為結膜惡性黑色素瘤 。術后48例進行9個月～5年隨訪，15例眶內容物剜除術，3例死于肺及顱腦轉移；14例單純擴大腫瘤切除聯合液氮冷凍治療，2例死于肝轉移；19例單純擴大腫瘤切除術，6例分別死于肝、肺及顱腦轉移。 結論 早期診斷并選擇積極有效的手術治療是提高患者生存率，改善生存質量的重要手段。手術切除聯合液氮冷凍法可有效降低腫瘤復發，避免影響患者視覺質量和外觀，是治療結膜惡性黑色素瘤的一種有效方法。【Abstract】 Objective To investigate the surgical therapeutics for malignant melanoma of eyelid conjunctiva. Methods A total of 48 patients with monocular malignant melanoma of eyelid conjunctiva from January 1997 to January 2007 were collected. The scope of the melanoma involved lt;1/3 eyelid length and conjunctiva in 14, gt;1/3 eyelid length and part of conjunctival formix in 19, and upper and lower eyelid and most of the conjunctiva of medial and lateral canthus in 15. Eye socket exenteration,tumor resection combine with eyelid reconstruction, tumor resection were used. Results All of the patients were diagnosed as malignant melanoma of eyelid conjunctiva by pathological examination. The follow-up period was 9 months-5 years. Among the 15 patients who had undergone eye socket exenteration,3 died. Among the 14 patients who had undergone expand tumor resection combine with liquid nitrogen frozen, 2 died. Among the 19 patients who had undergone tumor resection combine with eyelid reconstruction, 6 died. Conclusion Tumor resection combine with liquid nitrogen frozen is effective on malignant melanoma of eyelid conjunctiva.
【摘要】 目的 研究ΔNP63/TAP63在上皮性卵巢腫瘤組織中的表達及其與臨床病理特征的關系。 方法 運用熒光定量聚合酶鏈反應方法檢測2002年-2004年54例卵巢上皮性腫瘤中ΔNP63/TAP63的基因水平。 結果 33例卵巢上皮細胞癌組織中ΔNP63的表達高于21例良性上皮性腫瘤中組織。卵巢上皮細胞癌中的表達強度與腫瘤組織病理學分期相關（Plt;0.05），良性腫瘤的表達低于惡性腫瘤（Plt;0.05）。ΔNP63的表達高于TAP63（Plt;0.05）；各組間TAP63的表達差異無統計學意義（Pgt;0.05）。 結論 ΔNP63在上皮性卵巢癌中高表達，可能成為上皮性卵巢癌診斷及預后的分子標志物。【Abstract】 Objective To explore the expression of ΔNP63 / TAP63 in human epithelial ovarian tumor tissues and its relationship with the clinicopathological features. Methods Fluorescent quantitative PCR method was used to detect 54 cases of ΔNP63 / TAP63 gene level in 54 patients with epithelial ovarian tumors diagnosed between 2002 and 2004. Results ΔNP63 expression in the 33 cases of ovarian epithelial cell carcinoma was higher than that in the 21 cases of benign epithelial tumor tissue. The expression in ovarian epithelial cell carcinoma was concerned with the pathological staging of tumor (Plt;0.05); the expression in benign tumors was lower than that in the malignant tumors (Plt;0.05). In all cases, the expression of ΔNP63 was higher than that of TAP63 (Plt;0.05); the difference in the expression of TAP63 among the groups was not significant (Pgt;0.05). Conclusion ΔNP63 in epithelial ovarian cancer is highly expressed, which may become the molecular makers with diagnosis and prognosis of epithelial ovarian cancer diagnosis in the future.
